Direct in vivo strain measurements in human bone—A systematic literature review

Nazer, R. Al; Lanovaz, Joel L.; Kawalilak, Chantal E.; Johnston, James D.; Kontulainen, Saija

doi:10.1016/j.jbiomech.2011.08.004

Cited by 90 publications

(69 citation statements)

References 49 publications

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“…The predicted strain was consistent with the reported value of 0.3% (3000 microstrains) for typical activities (Yang et al 2011;Al Nazer et al 2012). The predicted strain within tibial bone exceeded this limit around the implant keel, for all tibias.…”

Section: Accepted Manuscriptsupporting

confidence: 89%

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Fixed and mobile-bearing total ankle prostheses: Effect on tibial bone strain

Terrier

Fernandes

Guillemin

et al. 2017

Clinical Biomechanics

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Please cite this article as: Alexandre Terrier, Caroline Sieger Fernandes, Maïka Guillemin, Xavier Crevoisier , Fixed and mobile-bearing total ankle prostheses: Effect on tibial bone strain, Clinical Biomechanics (2017Biomechanics ( ), doi: 10.1016Biomechanics ( /j.clinbiomech.2017 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPTA C C E P T E D M A N U S C R I P T 3 AbstractBackground Total ankle replacement is associated to a high revision rate. To improve

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Section: Accepted Manuscriptsupporting

confidence: 89%

“…The loading considered here was however extreme. The predicted strains suggest that bone microdamage might occur around the blade and at the border of the plate (Al Nazer et al 2012). This is also consistent with the prediction of bone-implant interfacial stress, which were located around the keel and at the rim of the plate.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Fixed and mobile-bearing total ankle prostheses: Effect on tibial bone strain

Terrier

Fernandes

Guillemin

et al. 2017

Clinical Biomechanics

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“…The predicted strain within tibial bone exceeded this limit around the implant keel, for all tibias. The predicted strains suggest that bone microdamage might occur around the blade and at the border of the plate (Al Nazer et al, 2012). The strain values were higher when the average HU was lower, or when the bone support under the plate was not symmetrical.…”

Section: Discussionmentioning

confidence: 96%

Development and experimental validation of a finite element model of total ankle replacement

Terrier

Larrea

Guerdat

et al. 2014

Journal of Biomechanics

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a b s t r a c tTotal ankle replacement remains a less satisfactory solution compared to other joint replacements. The goal of this study was to develop and validate a finite element model of total ankle replacement, for future testing of hypotheses related to clinical issues. To validate the finite element model, an experimental setup was specifically developed and applied on 8 cadaveric tibias. A non-cemented press fit tibial component of a mobile bearing prosthesis was inserted into the tibias. Two extreme anterior and posterior positions of the mobile bearing insert were considered, as well as a centered one. An axial force of 2 kN was applied for each insert position. Strains were measured on the bone surface using digital image correlation. Tibias were CT scanned before implantation, after implantation, and after mechanical tests and removal of the prosthesis. The finite element model replicated the experimental setup. The first CT was used to build the geometry and evaluate the mechanical properties of the tibias. The second CT was used to set the implant position. The third CT was used to assess the bone-implant interface conditions. The coefficient of determination (R-squared) between the measured and predicted strains was 0.91. Predicted bone strains were maximal around the implant keel, especially at the anterior and posterior ends. The finite element model presented here is validated for future tests using more physiological loading conditions.

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“…A mathematical model was used to calculate a load required to mimic changes in strain equivalent to physiological-scale effects that have been reported previously. 23 A global gene expression microarray was carried out to identify candidate transcriptional regulators and signaling mechanisms induced by mechanical stimulation.…”

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confidence: 99%

Gene Expression Responses to Mechanical Stimulation of Mesenchymal Stem Cells Seeded on Calcium Phosphate Cement

Gharibi

Cama

Capurro

et al. 2013

Tissue Engineering Part A

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Introduction: The aim of the study reported here was to investigate the molecular responses of human mesenchymal stem cells (MSC) to loading with a model that attempts to closely mimic the physiological mechanical loading of bone, using monetite calcium phosphate (CaP) scaffolds to mimic the biomechanical properties of bone and a bioreactor to induce appropriate load and strain. Methods: Human MSCs were seeded onto CaP scaffolds and subjected to a pulsating compressive force of 5.5 -4.5 N at a frequency of 0.1 Hz. Early molecular responses to mechanical loading were assessed by microarray and quantitative reverse transcription-polymerase chain reaction and activation of signal transduction cascades was evaluated by western blotting analysis. Results: The maximum mechanical strain on cell/scaffolds was calculated at around 0.4%. After 2 h of loading, a total of 100 genes were differentially expressed. The largest cluster of genes activated with 2 h stimulation was the regulator of transcription, and it included FOSB. There were also changes in genes involved in cell cycle and regulation of protein kinase cascades. When cells were rested for 6 h after mechanical stimulation, gene expression returned to normal. Further resting for a total of 22 h induced upregulation of 63 totally distinct genes that were mainly involved in cell surface receptor signal transduction and regulation of metabolic and cell division processes. In addition, the osteogenic transcription factor RUNX-2 was upregulated. Twenty-four hours of persistent loading also markedly induced osterix expression. Mechanical loading resulted in upregulation of Erk1/2 phosphorylation and the gene expression study identified a number of possible genes (SPRY2, RIPK1, SPRED2, SERTAD1, TRIB1, and RAPGEF2) that may regulate this process. Conclusion:The results suggest that mechanical loading activates a small number of immediate-early response genes that are mainly associated with transcriptional regulation, which subsequently results in activation of a wider group of genes including those associated with osteoblast proliferation and differentiation. The results provide a valuable insight into molecular events and signal transduction pathways involved in the regulation of MSC osteogenic differentiation in response to a physiological level of mechanical stimulation.

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Direct in vivo strain measurements in human bone—A systematic literature review

Cited by 90 publications

References 49 publications

Fixed and mobile-bearing total ankle prostheses: Effect on tibial bone strain

Fixed and mobile-bearing total ankle prostheses: Effect on tibial bone strain

Development and experimental validation of a finite element model of total ankle replacement

Gene Expression Responses to Mechanical Stimulation of Mesenchymal Stem Cells Seeded on Calcium Phosphate Cement

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