The repair of bone defects is an important focus area in orthopedic surgery; the current surgical treatments depending on the lesion size and severity include microfracture, autograft, allograft, and total joint replacement. 1,2 However, those treatments have drawbacks, including the quality inconsistency of the tissue obtained from microfracture, 3 limitations in the autograft supply, immune rejection of allograft tissue, 4,5 as well as wear and loosening of prostheses. 2 Bone tissue engineering therapies are attractive due to their potential to create biological substitutes that can maintain, replace, or regenerate bone tissue. 1,6 Ideally, a bone scaffold should closely mimic the physiological properties of natural bone tissue; for example, a tissue scaffold should possess mechanical properties that match the host tissue as well as appropriate porosity and interconnectivity for nutrient delivery and tissue regeneration. 7,8 Particularly, bone scaffolds with pores larger than 300 µm facilitate the penetration of mineralized tissue and cell migration toward the scaffold center, stimulating nutrient supply and waste product removal. 6,9 In addition, the main chemical components