Direct isolation of ultra-late (C-fibre) evoked brain potentials by CO2 laser stimulation of tiny cutaneous surface areas in man

Bragard, Dominique; Chen, A C; Plaghki, Léon

doi:10.1016/0304-3940(96)12604-5

Cited by 160 publications

(76 citation statements)

References 22 publications

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“…The motor withdrawal evoked by laser heat is analogous to that elicited by slower forms of heat stimulation (Willer et al, 1979;Schouenborg et al, 1992;Bragard et al, 1996;Plaghki et al, 1998) but has the advantage that more is known about its underlying circuitry (Danneman et al, 1994). Initiation of the laser Figure 3.…”

Section: Discussionmentioning

confidence: 99%

Discharge of Raphe Magnus on and offCells Is Predictive of the Motor Facilitation Evoked by Repeated Laser Stimulation

Foo

Mason

2003

J. Neurosci.

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Medullary raphe magnus (RM) ON and OFF cells are thought to modulate spinal nociception by gating withdrawals evoked by noxious stimulation. To test whether withdrawal initiation is the target of RM modulation, we examined the relationship between ON and OFF cell discharge and motor withdrawal evoked by noxious laser heat in halothane-anesthetized rats. The cellular responses of both cell types began during the 50 msec after onset of the tail flick, peaked within 200 msec, and outlasted the duration of the motor reaction. Thus, it is unlikely that the target of ON and OFF cell modulation is withdrawal initiation; instead, ON and OFF cells may modulate reactions to repeated noxious stimulation. We therefore tested whether laser heat-evoked changes in RM cell discharge were predictive of the modulatory effects of one noxious stimulus on the reaction to a subsequent noxious stimulus. Two pulses of laser heat were presented at interpulse intervals of 0.8, 2.0, or 10.0 sec. The motor withdrawal evoked by the second pulse was significantly enhanced relative to that evoked by the first pulse. The observed motor enhancement depended on supraspinal input because it was not present in spinalized rats. Comparison of the relative changes in motor and cellular activity preceding double laser heat stimulation revealed parallel changes between motor facilitation, decreases in OFF cell discharge, and increases in ON cell discharge. This finding suggests a preparatory role for RM ON and OFF cells in enhancing reactions to a noxious stimulus that closely follows another noxious stimulus.

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Section: Discussionmentioning

confidence: 99%

Discharge of Raphe Magnus on and offCells Is Predictive of the Motor Facilitation Evoked by Repeated Laser Stimulation

Foo

Mason

2003

J. Neurosci.

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“…The Aδ response rate can likely be further increased by increasing the grid diameter as was demonstrated in other studies [6,7]. In this study, the theory presented by Plaghki and Mouraux [2] to determine the probability of not stimulating fibers was used to determine the probability of selective Aδ-or C-fiber activation.…”

Section: Discussionmentioning

confidence: 68%

“…This curve is experimentally validated in this study. To increase the probability of selective Aδ-or C-fiber activation, the application of a spatial filter seems a feasible method based on the differences in epidermal nerve fiber distribution [2,6].…”

Section: Differences In Epidermal Nerve Fiber Densitymentioning

confidence: 99%

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Selective Laser Stimulation of Aδ- or C-Fibers Through Application of a Spatial Filter: A Study in Healthy Volunteers

et al. 2016

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Background: Pain is perceived through different pathways involving thinly myelinated Aδ-fibers and unmyelinated C-fibers. Aδ-fibers are responsible for a quick, sharp pain, whereas C-fibers relate to a lateonset, burning sensation. Several studies suggest that it is essential to investigate nociceptive fibers separately and in relation to each other. The aim of this study was to selectively stimulate Aδ-and C-fibers using a 980-nm diode laser by varying the laser settings and the stimulated surface area in healthy subjects.

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“…The reason for this is beyond the purpose of this paper, but the interested reader can consult detailed papers on this matter. [16][17] Selective excitation of the amyelinic C fibres can be achieved by diverse procedures, mainly based on the elimination of the Aδ component by a pressure-block, 18 stimulation of tiny skin areas 19 or stimulation of large areas at low intensity. [20][21] All of these manipulations yield the so-called 'ultra-late' LEPs, rising to about 1,000ms after stimulation and depending exclusively on C-fibre activation.…”

mentioning

confidence: 99%

Diagnostic Role of Laser-Evoked Potentials in Central Neuropathic Pain

García-Larrea¹,

Godinho²

2007

European Neurological Review

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Direct isolation of ultra-late (C-fibre) evoked brain potentials by CO2 laser stimulation of tiny cutaneous surface areas in man

Cited by 160 publications

References 22 publications

Discharge of Raphe Magnus on and offCells Is Predictive of the Motor Facilitation Evoked by Repeated Laser Stimulation

Discharge of Raphe Magnus on and offCells Is Predictive of the Motor Facilitation Evoked by Repeated Laser Stimulation

Selective Laser Stimulation of Aδ- or C-Fibers Through Application of a Spatial Filter: A Study in Healthy Volunteers

Diagnostic Role of Laser-Evoked Potentials in Central Neuropathic Pain

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