Direct Kinetic Determination of Bromhexine Hydrochloride in Pharmaceutical Formulations

Macrocycleversus podant-type neutral ionophore in potentiometric detection of mucolytic agents following separation by various HPLC modes

“…Simultaneous determination of bromhexine in pharmaceutical samples containing antibiotics [ 13], salbutamol [17], antimicrobial preservatives [18] or sulfonamides [26] have also been described. In HPLC procedures, UV detection at 246 nm is mostly used for individual detection of ambroxol or bromhexine with a sensitivity of 2.0 • 10 7M [18][19][20][21][22][23][24][25].…”

“…For individual determination of ambroxol hydrochloride or bromhexine hydrochloride in pharmaceutical preparations a range of spectrophotometric [13,14], GC [15,16], flow-injection [14], TLC [17], HPLC [18][19][20][21][22][23][24][25], CE [26] and capillary isotachophoretic [27] procedures have been developed. Simultaneous determination of bromhexine in pharmaceutical samples containing antibiotics [ 13], salbutamol [17], antimicrobial preservatives [18] or sulfonamides [26] have also been described.…”

RETRACTED: Bromhexine-Selective PVC Membrane Electrode Based on Bromhexinium Tetraphenylborate

“…However, BHX interfered with the determination of penicillins such as ampicillin and amoxycillin, which are present in many pharmaceutical preparations of BHX. Gala et al (21) described a direct kinetic method for the determination of BHX in pharmaceutical formulations.…”

Simultaneous determination of salbutamol sulphate and bromhexine hydrochloride in tablets by reverse phase liquid chromatography

“…As found from the literature, salbutamol sulphate and bromhexine hydrochloride can be estimated individually by HPLC and spectrometric methods. Salbutamol sulphate and bromhexine hydrochloride has been reported to be estimated by spectrometric methods[ 1 – 8 ]. Salbutamol sulphate and bromhexine hydrochloride have been simultaneously determined by spectrometric[ 9 ] and HPLC methods[ 10 ].…”