1982
DOI: 10.1152/ajpheart.1982.243.6.h1018
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Direct measurement of microvessel hematocrit, red cell flux, velocity, and transit time

Abstract: A method is presented for the in vivo study of red cell flow dynamics. The method permits direct measurement of the red cell volume fraction in microvessel blood without resort to in vitro calibration curves. Furthermore, the method does not require extensive mathematical manipulation and can be applied to any microvascular network in any tissue. The method also enables direct measurement of red cell velocity, flux, and capillary transit time. Fluorescently labeled erythrocytes in tracer quantities, but known … Show more

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Cited by 146 publications
(142 citation statements)
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“…were both considerably higher than the established values for young rats (Sarelius & Duling, 1982;Kindig et al, 2002;Russell et al, 2003). Indeed, the present V RBC value is even higher than reported by Russell et al (Russell et al, 2003) which may be the consequence of the slightly older age range (i.e., up to 30 vs. 28 months) in the rats in the present investigation.…”
Section: Comparisons To Previous Researchcontrasting
confidence: 70%
“…were both considerably higher than the established values for young rats (Sarelius & Duling, 1982;Kindig et al, 2002;Russell et al, 2003). Indeed, the present V RBC value is even higher than reported by Russell et al (Russell et al, 2003) which may be the consequence of the slightly older age range (i.e., up to 30 vs. 28 months) in the rats in the present investigation.…”
Section: Comparisons To Previous Researchcontrasting
confidence: 70%
“…In each of the microvessels that we analyzed, ESL thickness estimates showed little sensitivity to values of K Ͼ 10 9 dyn⅐s͞cm 4 (see D in Figs. [15][16][17][18][19][20][21][22][23][24][25][26].…”
Section: Resultsmentioning
confidence: 99%
“…In general, neither H T nor H D are equal to the systemic hematocrit, H sys , which is obtained from a large artery or vein, because red cells and plasma distribute unevenly at microvascular bifurcations (13). Measurements of H T in microvessels in vivo have been attempted either by using microphotometric methods (8,14) or by counting labeled red cells (15), neither of which are reliable in microvessels more than Ϸ20 m in diameter. Measurements of H D have been attempted in microvessels in vivo either by micropipette aspiration and centrifugation (16), which is extremely cumbersome and feasible only in some tissues, or by a microphotometric method (13), which assumes the same Fåhraeus effect in glass tubes and microvessels of the same size.…”
mentioning
confidence: 99%
“…(2) The hematocrit in capillary vessels is approximately one half of that in systemic circulation (Farheus effect) [33,34], and is therefore at risk of underestimating its true value. (3) The CI values of the ventricular cavity and myocardium must be within the dynamic range of the system.…”
Section: Mulamentioning
confidence: 99%