Although the current regulation of user-side voltage takes into account the needs of users, it mostly adopts rigid regulation, which leads to the increase of carbon emissions in energy consumption of the power grid. In order to improve the above defects and maximize the energy saving of the power grid, a flexible adjustment method for the voltage on the large power user side under the constraint of carbon emission is studied. Through the establishment of user side zip model, the user side voltage flexible control load is analyzed. Taking energy consumption, power factor, three-phase imbalance and time sharing as indicators, the carbon emission constraints of power supply are calculated. Based on the actual demand response of the user side, the hierarchical coordinated control of voltage is realized. In the power grid experiment, the regulation method under the constraint of carbon emission can reduce the carbon emission, and the power energy loss during regulation is reduced by about 3/8 on average, and the practical application effect is better.