Direct one-pot synthesis of glutathione capped hydrophilic FePt-CdS nanoprobe for efficient bimodal imaging application

Jha, Deepak Kumar; Saikia, Koushik; Chakrabarti, Srijita; Bhattacharya, Kakoli; Varadarajan, Komanduri S.; Patel, Anant B.; Goyary, Danswrang; Chattopadhyay, Pronobesh; Deb, Pritam

doi:10.1016/j.msec.2016.11.077

Cited by 21 publications

(12 citation statements)

References 43 publications

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“…Recently, several attempts have been made to study the effect of different classes of nanoparticles on cancer cells [ 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 ]. (Interestingly, fluorescent magnetic nanoparticles have been used in a wide range of applications in biological systems such as diagnostic, bioimaging, and drug delivery [ 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 ] and also in the detection of foodborne pathogens [ 46 ]), but there is no report of use of fluorescent magnetic submicronic polymer nanoparticles (FMSP-nanoparticles) in the treatment of human breast cancer cells. In the present study, we tested the effect of FMSP-nanoparticles on human breast cancer MCF-7 cells.…”

Section: Introductionmentioning

confidence: 99%

FMSP-Nanoparticles Induced Cell Death on Human Breast Adenocarcinoma Cell Line (MCF-7 Cells): Morphometric Analysis

et al. 2018

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Currently, breast cancer treatment mostly revolves around radiation therapy and surgical interventions, but often these treatments do not provide satisfactory relief to the patients and cause unmanageable side-effects. Nanomaterials show promising results in treating cancer cells and have many advantages such as high biocompatibility, bioavailability and effective therapeutic capabilities. Interestingly, fluorescent magnetic nanoparticles have been used in many biological and diagnostic applications, but there is no report of use of fluorescent magnetic submicronic polymer nanoparticles (FMSP-nanoparticles) in the treatment of human breast cancer cells. In the present study, we tested the effect of FMSP-nanoparticles on human breast cancer cells (MCF-7). We tested different concentrations (1.25, 12.5 and 50 µg/mL) of FMSP-nanoparticles in MCF-7 cells and evaluated the nanoparticles response morphometrically. Our results revealed that FMSP-nanoparticles produced a concentration dependent effect on the cancer cells, a dose of 1.25 µg/mL produced no significant effect on the cancer cell morphology and cell death, whereas dosages of 12.5 and 50 µg/mL resulted in significant nuclear augmentation, disintegration, chromatic condensation followed by dose dependent cell death. Our results demonstrate that FMSP-nanoparticles induce cell death in MCF-7 cells and may be a potential anti-cancer agent for breast cancer treatment.

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Section: Introductionmentioning

confidence: 99%

FMSP-Nanoparticles Induced Cell Death on Human Breast Adenocarcinoma Cell Line (MCF-7 Cells): Morphometric Analysis

et al. 2018

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“…In this case, the glutathione coating provided biocompatibility and ligand attachment sites on the nanoprobes. 19 Core-shell QDs such as CdSe@ZnS were employed in the quantitative determination of micrococcal nuclease, the extracellular nuclease of Staphylococcus aureus. In this case, the QDs were conjugated to a single-stranded DNA (ssDNA)-fluorescent dye FRET probe.…”

Section: Imagingmentioning

confidence: 99%

Quantum dots in imaging, drug delivery and sensor applications

Matea

Mocan

Tabaran

et al. 2017

IJN

526

231

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Quantum dots (QDs), also known as nanoscale semiconductor crystals, are nanoparticles with unique optical and electronic properties such as bright and intensive fluorescence. Since most conventional organic label dyes do not offer the near-infrared (>650 nm) emission possibility, QDs, with their tunable optical properties, have gained a lot of interest. They possess characteristics such as good chemical and photo-stability, high quantum yield and size-tunable light emission. Different types of QDs can be excited with the same light wavelength, and their narrow emission bands can be detected simultaneously for multiple assays. There is an increasing interest in the development of nano-theranostics platforms for simultaneous sensing, imaging and therapy. QDs have great potential for such applications, with notable results already published in the fields of sensors, drug delivery and biomedical imaging. This review summarizes the latest developments available in literature regarding the use of QDs for medical applications.

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“…After 1 h of incubation, different concentrations of TiO 2 -NPs (10, 25, 50, 75, and 100 mg/mL) were added and incubated for 24 h. Subsequently, 20 mL of resazurin (100 mg/mL) was added to each well and incubated again for 1 h. The absorbance was then recorded at 570 nm using a microplate reader (SpectraMax Plus 384, Molecular Devices, San Jose, California, USA). Each sample was assayed in triplicate and the percentage cell viability was calculated by the following formula as described elsewhere (Jha et al, 2017) Cell viability…”

Section: In Vitro Experimentsmentioning

confidence: 99%

Exploration of cytotoxic and genotoxic endpoints following sub-chronic oral exposure to titanium dioxide nanoparticles

et al. 2019

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Health hazards of titanium dioxide nanoparticles (TiO2-NPs) have raised severe concerns because of the paucity of information regarding the toxic effects among the population. In the present research, the in vitro and in vivo cytotoxic potential of TiO2-NPs were evaluated using flow cytometric techniques. Further, in vitro and in vivo genotoxic endpoints were estimated by means of comet, micronucleus (MN), and chromosomal aberration (CA) assays. In vitro analysis was performed at the concentration range of 10–100 µg/mL using murine RAW 264.7 cells. In vivo experiments were conducted on Albino mice (M/F) by exposing them to 200 and 500 mg/kg TiO2-NPs for 90 days. Decreased percentage of cell viability with higher doses of TiO2-NPs was evident in both in vitro and in vivo flow cytometric analysis. Further, an impaired cell cycle (G0/G1, S, and G2/M) was reflected in the present investigation following the exposure to TiO2-NPs. Increased comet scores such as tail length, % DNA in tail, tail moment, and olive moment were also observed with the higher doses of TiO2-NPs in vitro and in vivo comet assays. Finally, the in vivo MN and CA assays revealed the formation of MN and chromosomal breakage following the exposure to TiO2-NPs.

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Direct one-pot synthesis of glutathione capped hydrophilic FePt-CdS nanoprobe for efficient bimodal imaging application

Cited by 21 publications

References 43 publications

FMSP-Nanoparticles Induced Cell Death on Human Breast Adenocarcinoma Cell Line (MCF-7 Cells): Morphometric Analysis

FMSP-Nanoparticles Induced Cell Death on Human Breast Adenocarcinoma Cell Line (MCF-7 Cells): Morphometric Analysis

Quantum dots in imaging, drug delivery and sensor applications

Exploration of cytotoxic and genotoxic endpoints following sub-chronic oral exposure to titanium dioxide nanoparticles

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