Direct production of l (+) lactic acid in a continuous and fully membrane-integrated hybrid reactor system under non-neutralizing conditions

Efficient magnesium lactate production with in situ product removal by crystallization

“…Activated carbon absorption, ion exchange resins and solvent extraction are complicated, involving regeneration, low concentration and poor productivity (Garrett et al, 2015;Gao et al, 2009Gao et al, , 2011. Low concentrations were also reported when membranes were used in the ISPR process (Dey and Pal, 2012;Sikder et al, 2012;Zhang et al, 2014). Rhizopus oryzae immobilized on a Rotating Fibers Bed produced a high yield (Tay and Yang, 2002), but at a relative low productivity.…”

“…The magnesium reagent could be economically recovered and reused in the production of L-lactic acid, which avoids the waste production (e.g. CaSO 4 ) in fermentation neutralized with a calcium compound (Dey and Pal, 2012). And unlike other complicated ISPR techniques, magnesium lactate crystallization was performed automatically at fermentation temperature, requiring neither seed crystal addition, nor cooling or re-heating.…”

Modelling and simulation of continuous L (+) lactic acid production from sugarcane juice in membrane integrated hybrid-reactor system

“…Models for a membrane-integrated continuous process for production of lactic acid from a cheap and renewable carbon source considering the relevant kinetics and transport phenomena particularly during nanofiltration are practically absent in the literature. But development of such a mathematical model has the potential of bringing very successful green designs [8] on lactic acid production to the field through enhanced scale up confidence.…”

“…However, in most of the studies, a single membrane separation step like ultrafiltration, nanofiltration or reverse osmosis has been coupled with the fermentation process under pH-controlled regime. Such a process in most of the cases have ended up with production of lactate salt instead of lactic acid directly, necessitating further processing and adding to the cost [7,8]. Moreover, compared to the experimental studies, modelling studies on the production of lactic acid in a membrane-integrated hybrid process has been scanty.…”

Produção de bacteriocina por Bifidobacterium lactis a partir de soro de leite

“…After its recovery and purification by distillation, hydrochloric acid or sulfuric acid is added to hydrolyze lactonitrile to lactic acid, which is then esterified with methanol to produce methyl lactate, and this is recovered and purified by distillation. The purified methyl lactate is finally hydrolyzed in acidic aqueous solution to lactic acid and methanol, the latter being recycled in the same process (Dey & Pal, 2012;Narayanan, Roychoudhury, & Srivastava, 2004a). Other chemical routes for lactic acid synthesis include base-catalyzed degradation of sugars, oxidation of propylene glycol, carbon monoxide and water at high temperature and pressure, hydrolysis of chloropropionic acid, and nitric acid oxidation of propylene, among others (John, Sukumaran, Nampoothiri, & Pandey, 2007).…”