2000
DOI: 10.1016/s8756-3282(00)00358-6
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Direct stimulation of osteoclastic bone resorption by bone morphogenetic protein (BMP)-2 and expression of BMP receptors in mature osteoclasts

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Cited by 310 publications
(240 citation statements)
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“…52 BMP production by megakaryocytes does represent such a candidate because osteoclasts are known to possess BMP receptors and are stimulated by BMPs. [53][54][55] Whether BMP expression explains the bone phenotype in the hTg G233V model can be examined in future studies.…”
Section: Discussionmentioning
confidence: 99%
“…52 BMP production by megakaryocytes does represent such a candidate because osteoclasts are known to possess BMP receptors and are stimulated by BMPs. [53][54][55] Whether BMP expression explains the bone phenotype in the hTg G233V model can be examined in future studies.…”
Section: Discussionmentioning
confidence: 99%
“…Previously, there have been reports of immunohistochemical localization of BMP-2, -4, and -6 in the osteoclasts of metaphyseal bone (Anderson et al 2000) and BMP-3 and -6 in osteoclasts during osteophyte formation (Zoricic et al 2003). BMP receptors IA and II have been reported to be present in mature osteoclasts (Kaneko et al 2000). However, no comprehensive study of BMP expression and localization in murine osteoclasts has been done to date.…”
Section: Discussionmentioning
confidence: 99%
“…Recently, recombinant BMPs have also been shown to support osteoclastic differentiation in cultures (Kaneko et al 2000;Okamoto et al 2006;Wutzl et al 2006). The coupling of bone resorption to bone formation has been reported by many researchers, including Parfitt (1982Parfitt ( ,2004, Martin (Martin and Rodan 2001;Martin and Sims 2005), and Mundy (Mundy 1993;Mundy and Elefteriou 2006).…”
mentioning
confidence: 96%
“…The change of some soluble factors in the serum of this patient by glucocorticoid use and immobilization might be responsible for enhancing the level of ALP, OCN and BMP-2 in osteoblast. Furthermore, increased bone resorption indices may be due to BMP-2, stimulation of bone resorption by enhanced osteoclast formation, and osteoclastic activity [14,15]. Okamoto et al [16] reported that mice overexpressing BMP-4 in bone developed severe osteopenia with increased osteoclast number.…”
Section: Discussionmentioning
confidence: 99%