Direct synthesis of silver nanoparticles modified spherical mesoporous silica as efficient antibacterial materials

Joardar, Sutapa; Adams, Marisa L.; Biswas, Rima; Deodhar, Gauri; Metzger, Kara E.; Deweese, Kendall; Davidson, Malcolm R.; Richards, Ryan M.; Trewyn, Brian G.; Biswas, Papu

doi:10.1016/j.micromeso.2020.110824

Cited by 26 publications

(6 citation statements)

References 72 publications

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“…Silver-containing systems were used in the past for topical antibacterial treatments of burns and wounds; for example, silver sulfadiazine was introduced in the 1970s as an antibacterial agent [ 8 ]. In the same context, MSNs have previously been applied as a support of silver nanoparticles against several bacteria [ 9 , 10 , 11 ]. However, the use of MSN as a support for silver chloride nanoparticles is still very limited [ 12 , 13 ] and has not yet been studied against the bacterium P. aeruginosa .…”

Section: Introductionmentioning

confidence: 99%

Hybrid Nanosystems Based on Nicotinate-Functionalized Mesoporous Silica and Silver Chloride Nanoparticles Loaded with Phenytoin for Preventing Pseudomonas aeruginosa Biofilm Development

et al. 2022

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Pseudomonas aeruginosa (PA) is one of the most common bacteria isolated from chronic wounds and burns. Its treatment is a challenge due to antimicrobial drug resistance and biofilm formation. In this context, this study aimed to perform the synthesis and full characterization of hybrid nanosystems based on mesoporous silica nanoparticles (MSNs) functionalized with a nicotinic ligand and silver chloride nanoparticles, both phenytoin sodium (Ph)-loaded and unloaded, to evaluate the antibacterial properties against three different strains of PA (including two clinical strains) in a planktonic state and as biofilms. Ph is a well-known proliferative agent, which was incorporated into the hybrid nanomaterials to obtain an effective material for tissue healing and prevention of infection caused by PA. The Ph-loaded materials promoted a quasi-complete inhibition of bacterial growth in wound-like medium and biofilm development, with values of 99% and 96%, respectively, with selectivity indices above the requirements for drugs to become promising agents for the topic preventive treatment of chronic wounds and burns.

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Section: Introductionmentioning

confidence: 99%

Hybrid Nanosystems Based on Nicotinate-Functionalized Mesoporous Silica and Silver Chloride Nanoparticles Loaded with Phenytoin for Preventing Pseudomonas aeruginosa Biofilm Development

et al. 2022

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“…By comparisons the results of other researches we detected that Ru-based Ag-decorated-MSNs reveal effective antimicrobial function in lower MIC and MBC values against certain types of bacteria and fungi in comparison with Ag-decorated MSNs 54 – 57 . It is suggested that adding Ru extract to silicon mesopore could enhance the antimicrobial characteristics of Ag-MSN.…”

Section: Resultsmentioning

confidence: 56%

An intriguing approach toward antibacterial activity of green synthesized Rutin-templated mesoporous silica nanoparticles decorated with nanosilver

Abbasi

Gholizadeh

Kasaee

et al. 2023

Sci Rep

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In recent years, mesoporous silica nanoparticles (MSNs) have been applied in various biomedicine fields like bioimaging, drug delivery, and antibacterial alternatives. MSNs could be manufactured through green synthetic methods as environmentally friendly and sustainable synthesis approaches, to improve physiochemical characteristics for biomedical applications. In the present research, we used Rutin (Ru) extract, a biocompatible flavonoid, as the reducing agent and nonsurfactant template for the green synthesis of Ag-decorated MSNs. Transmission electron microscopy (TEM), zeta-potential, x-ray powder diffraction (XRD), fourier transform infrared (FTIR) spectroscopy analysis, scanning electron microscopy (SEM), brunauer–emmett–teller (BET) analysis, and energy-dispersive system (EDS) spectroscopy were used to evaluate the Ag-decorated MSNs physical characteristics. The antimicrobial properties were evaluated against Staphylococcus aureus (S. aureus), Escherichia coli (E. coli), and also different types of candida. The cytotoxicity test was performed by using the MTT assay. Based on the findings, the significant antimicrobial efficacy of Ru-Ag-decorated MSNs against both gram positive and gram negative bacteria and different types of fungi was detected as well as acceptable safety and low cytotoxicity even at lower concentrations. Our results have given a straightforward and cost-effective method for fabricating biodegradable Ag-decorated MSNs. The applications of these MSNs in the domains of biomedicine appear to be promising.

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“…PE is a predominant lipid found in organelles and cell membranes and plays a crucial role in maintaining membrane integrity [32]. Being a neutral aminophospholipid, it exhibits a diverse range of interactions, including its distinct capability to function as a molecular chaperone [33].…”

Section: σ-Surfaces and σ-Profiles For Cell Membrane Components And H...mentioning

confidence: 99%

Antibacterial performance enhancement using hydrophobic deep eutectic solvents: COSMO-RS prediction, experimental validation, and synergistic action with antibiotics

Elgharbawy,

Warsi Khan,

Mohd Noor

et al. 2024

Journal of Molecular Liquids

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Direct synthesis of silver nanoparticles modified spherical mesoporous silica as efficient antibacterial materials

Cited by 26 publications

References 72 publications

Hybrid Nanosystems Based on Nicotinate-Functionalized Mesoporous Silica and Silver Chloride Nanoparticles Loaded with Phenytoin for Preventing Pseudomonas aeruginosa Biofilm Development

Hybrid Nanosystems Based on Nicotinate-Functionalized Mesoporous Silica and Silver Chloride Nanoparticles Loaded with Phenytoin for Preventing Pseudomonas aeruginosa Biofilm Development

An intriguing approach toward antibacterial activity of green synthesized Rutin-templated mesoporous silica nanoparticles decorated with nanosilver

Antibacterial performance enhancement using hydrophobic deep eutectic solvents: COSMO-RS prediction, experimental validation, and synergistic action with antibiotics

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