2022
DOI: 10.3389/fbioe.2022.930551
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Direct three-dimensional printed egg white hydrogel wound dressing promotes wound healing with hitching adipose stem cells

Abstract: Current wound dressing based on hydrogel offers a promising way to accelerate the healing process, yet great challenges remain in the development of a highly integrated and efficient platform with the combination of therapeutic biomolecules and stem cells. Herein, a natural hydrogel wound dressing from egg white can be conveniently obtained by feasible physical crosslinking, the prepared hydrogel dressing features interconnected microporous channels, direct 3D printing, cytocompatibility, and intrinsic biomole… Show more

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Cited by 10 publications
(9 citation statements)
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“…Wang et al used 3D printing technology to prepare macroporous egg-white hydrogel dressings, which improved the viability and proliferation of loaded ADSCs. 32 However, the range of the pore size and stiffness of the scaffold is limited. Multi-scale scaffolds can better mimic natural extracellular matrix, which has a clear hierarchical organization from the nanoscale to macroscale.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Wang et al used 3D printing technology to prepare macroporous egg-white hydrogel dressings, which improved the viability and proliferation of loaded ADSCs. 32 However, the range of the pore size and stiffness of the scaffold is limited. Multi-scale scaffolds can better mimic natural extracellular matrix, which has a clear hierarchical organization from the nanoscale to macroscale.…”
Section: Resultsmentioning
confidence: 99%
“…ADSCs were obtained from subcutaneous adipose tissue (6 week-old C57BL/6 mice), as previously described. 32 Briefly, adipose tissue was collected, dissected, and digested with collagenase type I. ADSCs were resuspended in mesenchymal stem cell mediums after neutralization, centrifugation, and disposal of waste. The ADSCs suspensions were inoculated into T25 culture flasks and cultured in the incubator to the third–fifth generation range for subsequent experiments.…”
Section: Methodsmentioning
confidence: 99%
“…EW shows anti-inflammatory, antibacterial, and cell growth stimulation properties. The EW hydrogel accompanied with adipose-derived stem cells can promote fibroblast proliferation, angiogenesis, and collagen rearrangement to accelerate wound healing [45]. However, the effects of sericin and EW mixture on wound repair are rarely reported.…”
Section: Discussionmentioning
confidence: 99%
“…EWH was prepared according to a procedure that we have described previously. 49 Briefly, EW was prudentially separated from fresh eggs and mixed thoroughly via quick stirring to obtain a homogeneous liquid, which was blended with NaOH solution (0.5 M) at a ratio of 1 : 1 at 25 °C. After gelation, EWH was immersed in the ionic liquid Dulbecco's modified Eagle's medium (DMEM) with high glucose for ≥24 h to aid secondary crosslinking.…”
Section: Methodsmentioning
confidence: 99%