Effects of sericin and egg white on the inflammation of damaged skin in mice

Abstract

Background: Sericin and egg white (EW) have shown the ability to promote wound healing. However, there have been insufficient studies regarding the effects of sericin and EW mixtures on wound healing. This study aimed to investigate the effects of a hybrid sericin and EW solution on wound repair and inflammation-related indicators in mouse skin. Methods: In this work, sericin with a low molecular weight was first mixed with homogeneous EW to prepare a hybrid wound dressing. Histology evaluation, the expression of C-reactive protein (CRP) and inflammatory cytokines in mice were tested to determine the effects of this dressing on skin injuries in mice. Results: The results showed that sericin and the hybrid solution of sericin and EW effectively promoted wound healing in mouse skin. The wound recovery rates of mice 12 days after treatment with a medium dose of sericin (0.2 g/mL) and the same dosage of sericin with added EW were 1.32 and 1.65 times that of mice treated with phosphate buffer saline (PBS) as a control, respectively. In addition, the mixture solution was more effective in wound healing than sericin alone. Sericin with EW significantly reduced the expression of CRP and inflammatory cytokines in mice during wound healing. Conclusion: A sericin and EW hybrid solution can effectively shorten the time needed for wound healing and reduce inflammation-related indicators in mice, making it a promising candidate for wound dressing.

Application of stem cells in regeneration medicine

“…The inflammatory phase plays a crucial role in the wound healing process by inducing the recruitment of immune cells to prevent continued pathogenic damage to the organism. 69 , 70 During the hemostatic phase, stem cells migrate to the local wound site and induce vasoconstriction and platelet agglutination to promote blood clotting. 71 To produce hemostatic and anti‐inflammatory effects, a closed wound is temporarily formed on the wound surface.…”