It has been widely reported that breast reconstruction improves the quality of life of women who undergo mastectomy for breast cancer. <br />This approach provides many psychological advantages. Today, different techniques are available for the breast oncoplastic surgeon <br />that involve the use of breast implants and autologous tissues, also offering interesting results in terms of aesthetic and patient-reported <br />outcomes. On the other hand, advanced technologies and design strategies (i.e. design for additive manufacturing, reverse engineering) <br />may allow the development of customised porous structures with tailored morphological, mechanical, biological, and mass transport <br />properties. For this reason, the current study deals with the challenges, principles, and methods of developing 3D additive manufactured <br />structures in breast reconstructive surgery. Specifically, the aim was to design 3D additive manufactured poly(&epsilon;-caprolactone) scaffolds <br />with different architectures (i.e. lay-down patterns). Preliminary mechanical and biological analyses have shown the effect of the lay-<br />down pattern on the performances of the manufactured structures.