This paper has investigated an integrated control of active front steering (AFS) and direct yaw-moment control (DYC) for vehicle systems. First of all, the desired yaw rate and sideslip angle are estimated by using a two-degree-of-freedom (2-DOF) model of the vehicle system. On this basis, the actual sideslip angle is estimated by means of an observer. Then, the sliding mode control (SMC) is developed for AFS and DYC, respectively, to guarantee that the actual yaw rate and the sideslip angle track their reference signals. Additionally, the disturbance observer (DOB) technique is introduced to further improve the control performance. Finally, the simulation results validate the superiority of the AFS and DYC integrated control by using CarSim software during the following conditions: double lane change and side wind disturbance.