“…9,13,21,22 All studies adjusted for age, 2 adjusted for stroke severity, 21,22 and 2 adjusted for vascular risk factors. 13,21 Among studies not designed to examine sex differences, 5 reported that females had worse outcome than males in unadjusted analyses 10 and independent of age, 11,16,23,24 stroke severity, 23,24 prestroke disability, 23 comorbidities, 24 depression, 11 living alone, 11 recurrent stroke, 11 and cognitive impairments. 11 In contrast, others reported no association between sex and long-term functional outcomes in unadjusted analyses 11,12,20 or after adjusting for age, 16,18,[25][26][27][28][29][30][31] socioeconomic factors, 29 stroke severity, 17,18,25-27,29 -31 prestroke disability, 16,25,27 treatment, 27 mood, 18 and comorbidities.…”