Disappearance of both MALT lymphoma and hyperplastic polyps in the stomach after eradication of Helicobacter pylori

Kume, Keiichiro; Hirakoba, Machiko; Murata, Ikuo; Yoshikawa, Ichiro; Ōtsuki, Makoto

doi:10.1111/j.1572-0241.2001.04143.x

Cited by 17 publications

(10 citation statements)

References 3 publications

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“…In a 5-year review of gastric polyps, 109/153 (71.2%) were found to be hyperplastic polyps [2]. In this same series, fundic gland polyps accounted for 16.3% of all their polyps [2]. With the increasing use of proton pump inhibitors, the incidence of fundic gland polyps will in all likelihood increase and because of this they will probably represent the commonest gastric polyp encountered in biopsy material.…”

Section: Incidencementioning

confidence: 85%

“…This increased expression and inflammation has been suggested to play a role in the development of hyperplastic polyps by increasing epithelial cell turnover [13][14][15]. By the same token, partial or complete H. pylori eradication has been shown to cause complete regression or significant decrease in size of these polyps [13][14][15][16]. Furthermore, the polyps also recur with recurrence of H. pylori infection [15].…”

Section: Pathogenesismentioning

confidence: 95%

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Gastric Hyperplastic Polyps: A Review

2008

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Hyperplastic polyps represent the commonest polyp encountered in the stomach. They occur in patients of either gender and are commoner in the seventh decade of life. They are usually asymptomatic, small (less than 1 cm in diameter), solitary lesions occurring in the antrum but can present with dyspepsia, heartburn, abdominal pain, or upper gastrointestinal (GI) bleeding leading to anemia. Hyperplastic polyps almost never occur in normal gastric mucosa and are most commonly associated with chronic gastritis (Helicobacter pylori or autoimmune-induced). Pathologically, they are characterized by dilated, tortuous gastric foveoli set within an inflamed, edematous stroma. There is considerable histologic overlap especially with Ménétrier's disease and hamartomatous (juvenile or retention) polyps, and clinical input is mandatory to accomplish separation of these entities. Hyperplastic polyps arise as a by-product of repair to damaged mucosa. Dysplasia and malignancy are rarely associated with these polyps, which show an array of molecular aberrations. The importance of hyperplastic polyps for both gastroenterologist and pathologist lies in their association with other gastric mucosal pathology and mandates biopsy of adjacent mucosa and diligent search for accompanying pathology by the pathologist.

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Section: Incidencementioning

confidence: 85%

Section: Pathogenesismentioning

confidence: 95%

Gastric Hyperplastic Polyps: A Review

2008

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“…H. pylori infection has a worldwide distribution, and its prevalence ranges from 2% in developed countries to more than 90% in developing areas (17). This bacterium is the major cause of chronic gastritis and plays an important role in the pathogenesis of peptic ulcer disease, gastric carcinoma, and gastric mucosa-associated lymphoid tissue lymphoma (11,13,15,16,21,24,33). However, why only a minority of H. pylori-positive patients develop the severe associated diseases remains unclear.…”

mentioning

confidence: 99%

New Pathogenicity Marker Found in the Plasticity Region of theHelicobacter pyloriGenome

Santos

Queiroz²,

Ménard³

et al. 2003

J Clin Microbiol

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Comparison of gastric carcinoma and gastritis isolates showed the presence of genes, probably carcinoma associated (JHP947 and JHP940), that are situated in a Helicobacter pylori genome region (45 kb in J99 and 68 kb in 26695) called the "plasticity region." This region presents a great variability of DNA sequences. We investigated, by PCR, the presence of the JHP940 and JHP947 genes, as well as the presence of a third gene which seems to be associated with gastritis (HP986), on H. pylori strains isolated from 200 Brazilian patients, 79 of whom had gastric carcinomas and 53 of whom had duodenal ulcers, to confirm this association. Gastritis isolates (n ‫؍‬ 68) were included as a control. We also evaluated if these genes were related to the virulenceassociated cagA genotype. The present methodology did not permit definitive conclusions to be reached regarding the association between the JHP940 gene and gastric carcinoma or between the HP986 gene and gastritis. However, we showed that the JHP947 gene might be implicated in the development of both duodenal ulcer and gastric carcinoma. The presence of the JHP947 gene was associated with the cagA-positive genotype. The JHP947 gene is a novel virulence marker candidate of H. pylori.

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“…1 H. pylori is the major cause of chronic gastritis and plays an important role in the pathogenesis of peptic ulcer disease, gastric carcinoma (GC), and gastric mucosa-associated lymphoid tissue lymphoma. 2,3 However, why only a minority of H. pylori-positive patients develop the severe associated diseases remain unclear. Variation in clinical outcomes has been attributed to differences in environmental factors, bacterial strains, and host genetics.…”

Section: Introductionmentioning

confidence: 99%

Associations between the Plasticity Region Genes of Helicobacter pylori and Gastroduodenal Diseases in a High-Prevalence Area

Yakoob¹,

Abbas²,

Naz³

et al. 2010

Gut Liver

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Background/Aims: Genes associated with the Helicobacter pylori (H. pylori) plasticity region may play a role in the pathogenesis of H. pylori. We compared the genes jhp0940, jhp0947, and jhp0986 in H. pylori isolates from patients with different gastroduodenal diseases and in different age groups. Methods: The H. pylori hyperplasticity region genes jhp0940, jhp0947, and jhp0986 were studied by PCR. We also evaluated whether these genes were related to the cytotoxin-associated gene (cagA) and histology findings. Results: Of the patient cohort, 71 (62%) were positive for jhp0940, 67 (59%) for jhp0947, 12 (10%) for jhp0986, and 69 (60%) for cagA. jhp0940 (n=18, 67%) and jhp0947 (n=23, 85%) were found more frequently in duodenal ulcer (DU) patients than in gastritis patients (n=14, 39%; p=0.029 and p＜0.001, respectively). Gastric ulcer (GU) was more frequently associated with jhp0940 (17 patients, 77%; p=0.003) than with gastritis (14 patients, 39%). Gastric carcinoma (GC) was more strongly associated with both jhp0940 (22 patients, 76%; p=0.003) and jhp0947 (22 patients, 76%; p=0.003) than was gastritis (14 patients, 39%). jhp0947 was more frequently associated with chronic active inflammation (58 patients, 87%; p=0.009) than with chronic inflammation (9 patients, 13%). Multivariate analysis demonstrated that jhp0947 was associated with DU (odds ratio, 6.1; 95% confidence interval, 1.87-20). Conclusions: The genes jhp0947 and jhp0940 were identified in H. pylori isolates from patients with GC and DU, while jhp0940 was also isolated from patients with GU. jhp0947 was independently associated with DU. (Gut Liver 2010; 4:345-350)

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Disappearance of both MALT lymphoma and hyperplastic polyps in the stomach after eradication of Helicobacter pylori

Cited by 17 publications

References 3 publications

Gastric Hyperplastic Polyps: A Review

Gastric Hyperplastic Polyps: A Review

New Pathogenicity Marker Found in the Plasticity Region of theHelicobacter pyloriGenome

Associations between the Plasticity Region Genes of Helicobacter pylori and Gastroduodenal Diseases in a High-Prevalence Area

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