Disappearance of Immunoglobulin and Complement From the Arthus Reaction and Its Relevance to Studies of Vasculitis in Man

Cream, J. J.; Bryceson, A. D. M.; Ryder, G.

doi:10.1111/j.1365-2133.1971.tb06851.x

Cited by 92 publications

(33 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although experimentally in the Arthus reaction complexes have completely disappeared from the lesions by 18 hours (Cream et al, 1971), in man immunoglobulin and/or complement can frequently be identified in the lesions of vasculitis-IgG, IgM, and C3 (Schroeter et al, 1971), IgM, IgA, and C3 (Sams et al, 1975), and IgD, IgA, IgG, C3, and C5 (Weidner, 1975). In the present study DV IgM was present in one case (with C3) and DV IgA in another; properdin was found in two cases, and IgG and IgD in none.…”

Section: Discussionmentioning

confidence: 99%

Immunoglobulin and complement in normal skin.

Blenkinsopp¹,

Clayton²,

Haffenden³

1978

J Clin Pathol

View full text Add to dashboard Cite

al., 1974). In the present study, normal skin from 57 adults was examined for the standard IgG, IgA, IgM, and C3; in addition, 37 cases were examined for other complement stages (Clq and C4), properdin, transferrin, and IgD. Clq and C4 are found only in classical complement activation, whereas C3 (the main amplification step) is found in both classical and alternate pathway activation; properdin forms part of the activation sequence for the alternate pathway and is usually considered to indicate involvement of the alternate pathway-which, however, is also activated by a feedback loop in the classical pathway (Roitt, 1977); properdin has been described in affected and unaffected skin of patients with systemic lupus erythematosus (Schrager and Rothfield, 1976;Schroeter et al., 1976). Transferrin indicates nonspecific leakage of protein through vessel walls as it is neither an immunoglobulin nor involved in the

show abstract

Section: Discussionmentioning

confidence: 99%

Immunoglobulin and complement in normal skin.

Blenkinsopp¹,

Clayton²,

Haffenden³

1978

J Clin Pathol

View full text Add to dashboard Cite

show abstract

“…Histological findings of the skin of the two negative patients, however, were consistent with a complex-induced vasculitis. Experimental studies (Cream et al, 1971) have shown that the development of an inflammatory response soon makes it difficult to demonstrate the presence of complexes known to have been deposited in the skin. Though all our biopsy samples were taken within 24 hours of the appearance of a skin lesion this may still have been too late to allow the demonstration of complexes by immunofluorescence.…”

Section: Discussionmentioning

confidence: 99%

Allergic Complications of Meningococcal Disease II--Immunological Investigations

Greenwood¹,

Whittle²,

Bryceson³

1973

BMJ

Self Cite

View full text Add to dashboard Cite

Circulating antibody was detectable in three of the four patients about a week after the onset of the illness. A marked fall in the serum C. level occurred in two patients at about that time. Deposits of meningococcal antigen, immunoglobulin, and C, were detected in the synovial fluid white cells of the two patients studied and in one of three skin biopsies examined. These findings suggest that the arthritis and cutaneous lesions of meningococcal meningitis may be due to immune complex formation.

show abstract

“…This is not altogether surprising since the lesions were all thought to have been present for 1 week or longer. It has been shown in experi mental animals that the natural 'clearing-out' processes of inflammatory cells result in the removal of immunoglobulins and comple ment from blood vessel walls within 18-48 h after their deposition [27,28]. Similarly in leukocytoclastic vasculitis in man, immuno reactants were easily detectable up to 4 h after the lesion occurred, but then disap peared rapidly [29].…”

Section: Discussionmentioning

confidence: 92%

Possible Evidence for a Shwartzman Reaction in Pseudomembranous Colitis

Behan¹,

Mills²

1982

Digestion

View full text Add to dashboard Cite

Pseudomembranous colitis is a potentially fatal disorder associated with gastrointestinal surgery and the use of antibiotics. The aetiological agent has been shown to be Clostridium difficile but the pathogenesis of the disease is unknown. It has been suggested that the lesions produced are due to a local Shwartzman effect. Such an effect may be accompanied by activation of the serum complement system and we therefore looked for evidence of complement consumption in 4 patients with the diagnostic clinical and histological features of pseudomembranous colitis. Positive evidence was obtained suggesting that a Shwartzman phenomenon may be involved.

show abstract

Disappearance of Immunoglobulin and Complement From the Arthus Reaction and Its Relevance to Studies of Vasculitis in Man

Cited by 92 publications

References 6 publications

Immunoglobulin and complement in normal skin.

Immunoglobulin and complement in normal skin.

Allergic Complications of Meningococcal Disease II--Immunological Investigations

Possible Evidence for a Shwartzman Reaction in Pseudomembranous Colitis

Contact Info

Product

Resources

About