The timing and changes of appearance in immune complex deposits in the Arthus reaction in the guinea-pig have been studied by immunofluorescence. At first vessels are outlined, then surrounded by chunky deposits which by 8 hr. have dispersed into the tissues. Complexes have disappeared completely at 18 hr. The relevance of these observations to the study of cutaneous vasculitis in man is discussed.Acceptod for publication Soptomber 17th, 1970.
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