Evidence for Circulating Immune Complexes in Lepromatous Leprosy

Lsr2 of Mycobacterium leprae and Its Synthetic Peptides Elicit Restitution of T Cell Responses in Erythema Nodosum Leprosum and Reversal Reactions in Patients with Lepromatous Leprosy

“…These reactions are also of interest because immunological reconstitution has been shown to occur in anergic lepromatous leprosy during these episodes (25,26). ENL, earlier thought to be predominantly due to immune complexes (27,28), was shown in the 1980s (25,26,29,30) to be associated with the transient emergence of T cell functions. RR has also been associated with increases in delayed-type hypersensitivity (31).…”

Detection of immune complexes. The use of radioimmunoassays with Clq and monoclonal rheumatoid factor.

“…The possible role of immune complexes in a variety of basic immune mechanisms is currently under intensive study (1)(2)(3)(4) and in addition immune complexes have been shown to have an important role in a wide variety of diseases (5)(6)(7)(8)(9)(10)(11)(12). 1 Various techniques have been described for detecting immune complexes (13,14) but none so far have achieved the sensitivity, quantitative capacity, and simplicity for wide application.…”

Circulating Immune Complexes in Sickle Cell Hepatic Crises

“…This could be due to de creased circulation through hepatic sinus oids and/or defective Kupffer cell receptor function. IC are found in diseases with widely differing clinical signs and symptoms [1,2,6,11,13,17,23,26,29], It is possi ble that circulating IC play no role in the pathogenesis of liver disease in SCA hepatic crisis. The almost ubiquitous presence of a variety of complexes in liver diseases of dif ferent types might suggest that this was so [26].…”

“…They are found in numerous malignant and nonmalignant dis eases [1,6,11,13,17,23,27,29], IC have been demonstrated in sickle cell ane mia (SCA) where an autologous IC nephri tis may develop in some patients [14,22]. IC have also been found in patients with acute and chronic liver disease of varying etiologies [15,25,26], Liver dysfunction is common to SCA but the pathophysiology and the incidence of the various types are still not clear.…”