Disappearance of Macroamylasemia in a Celiac Patient After Treatment With a Gluten-Free Diet

Hyperamylasemia, Reactive Plasmacytosis, and Immune Abnormalities in a Patient with Celiac Disease

“…Previous work has reported that treatment with a glutenfree diet in CD can lead to disappearance of macroamylasemia [4]. In this patient, a gluten-free diet for 6 months resulted in a transient decrease in serum IgA (7.12 g/L) and IgG (19.04 g/L) and hyperamylasemia (1246 IU/L; Fig.…”

“…It has been reported that 6%-9.6% of patients with hyperamylasemia have macroamylasemia. Hyperamylasemia and macroamylase have been reported in patients with CD, and in a few cases, macroamylase decreased or resolved after a strict gluten-free diet [4,7,8].…”

Laboratory and clinical features of abnormal macroenzymes found in human sera

“…In 1989, Tozawa reported that the incidence of macroamylase in patients and in blood donors was 0.18% and 0.04%, respectively. A number of papers describing macroamylase have also been published since the 1990s [4,21,[88][89][90][91][92][93][94][95][96][97][98][99].…”

Macroamylasemia and Celiac Disease in a 6 -Year-Old Girl – Case Report

“…Macroamylasemia is defined as a biochemical disorder characterized by circulating complexes of amylase with macromolecules like immunoglobulins and polysaccharides, forming complexes known as macroamylase [1]. In association with macroamylasemia have been described several diseases, including IgA deficiency, celiac disease, lymphoma, HIV, carcinoma, ulcerative colitis, systemic lupus erythematosus, rheumatoid arthritis and liver disease [2][3][4][5][6][7][8][9][10][11][12][13]. Celiac disease (CD) is an immunemediated disorder resulting from a permanent intolerance to ingested gluten that results in inflammatory damage to the small intestinal mucosa.…”