Disappearance of the decrease in biting behavior induced by clenbuterol, a beta-adrenergic agonist, after chronic administration

Frances, Henriette; Danti, S.; Puech, A; Simon, Pierre

doi:10.1016/0091-3057(84)90231-4

Pharmacology Biochemistry and Behavior

1984

DOI: 10.1016/0091-3057(84)90231-4

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Disappearance of the decrease in biting behavior induced by clenbuterol, a beta-adrenergic agonist, after chronic administration

Henriette Frances¹,

S. Danti²,

A Puech³

et al.

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1985

1988

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Cited by 5 publications

References 22 publications

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Chronic beta-adrenergic stimulation increases in mice the sensitivity to methysergide and the number of cerebral high affinity serotonin binding sites (5-HT-1)

Frances¹,

Bulach²,

Simon

et al. 1986

J. Neural Transmission

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Reserpine administration in mice causes, among other effects an akinesia which can be reversed by the serotonin agonist-antagonist methysergide. The effect of methysergide is potentiated by clenbuterol, a beta-adrenergic agonist, which itself causes hypomotility. Potentiation is weak after a single injection of clenbuterol, but becomes much stronger after repeated administration for 12 days. This treatment also causes a 50% increase in the number of high affinity 5-HT-1 binding sites in the brain. This increase would explain the increased potency of methysergide against reserpine-induced akinesia. These results show that: a beta-adrenergic drug, clenbuterol modulates the serotoninergic system; this modulation takes its importance after chronic treatment only; this interrelation may be important in depressive illness since it is observed on a test used in the screening of antidepressant drugs.

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Chronic beta-adrenergic stimulation increases in mice the sensitivity to methysergide and the number of cerebral high affinity serotonin binding sites (5-HT-1)

Frances¹,

Bulach²,

Simon

et al. 1986

J. Neural Transmission

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Tolerance to or facilitation of pharmacological effects induced by chronic treatment with the beta-adrenergic stimulant clenbuterol

Frances

Diquet

Goldschmidt

et al. 1985

J. Neural Transmission

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The effect in mice of chronic administration of the beta-adrenergic agonist clenbuterol was studied using four pharmacological tests, two of which are predictive of antidepressant activity in man. The suppressive effect of acute administration of the beta-adrenergic agonist in two tests unrelated to antidepressant activity, locomotor activity and investigation of food, was attenuated after chronic treatment. However, in the two tests which are predictive of antidepressant activity, antagonism of reserpine induced hypothermia and potentiation of yohimbine toxicity, the effect of clenbuterol was greater following chronic treatment.

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Does a single priming injection of clenbuterol alter behavioral response to β-adrenoceptor agonists and antagonists in mice through a time-dependent process?

Martin

Soubrié

Simon

1985

European Journal of Pharmacology

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Disappearance of the decrease in biting behavior induced by clenbuterol, a beta-adrenergic agonist, after chronic administration

Cited by 5 publications

References 22 publications

Chronic beta-adrenergic stimulation increases in mice the sensitivity to methysergide and the number of cerebral high affinity serotonin binding sites (5-HT-1)

Chronic beta-adrenergic stimulation increases in mice the sensitivity to methysergide and the number of cerebral high affinity serotonin binding sites (5-HT-1)

Tolerance to or facilitation of pharmacological effects induced by chronic treatment with the beta-adrenergic stimulant clenbuterol

Does a single priming injection of clenbuterol alter behavioral response to β-adrenoceptor agonists and antagonists in mice through a time-dependent process?

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