Discoveries for Long Non-Coding RNA Dynamics in Traumatic Brain Injury

Lim, Kee-Joe; Yang, Sumin; Kim, Sung-Hyun; Chun, Sungkun; Joo, Jae‐Yeol

doi:10.3390/biology9120458

Cited by 9 publications

(3 citation statements)

References 93 publications

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“…H19 is a long non-coding RNA (LncRNA) that does not translate into protein, but can interact with miRNA as a competitive endogenous RNA and participate in the regulation of target gene expression [ 15 ]. And it is involved in the regulation of apoptosis and neurological diseases [ 16 , 17 , 18 , 19 ]. The expression of H19 is increased in brain injuries induced by AD [ 20 ], diabetes [ 21 ], ischemia/reperfusion [ 22 ], epilepsy [ 23 ], and oxygen and glucose deprivation [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

Methionine Restriction Improves Cognitive Ability by Alleviating Hippocampal Neuronal Apoptosis through H19 in Middle-Aged Insulin-Resistant Mice

Feng

Jiang

et al. 2022

Nutrients

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LncRNA H19 has been reported to regulate apoptosis and neurological diseases. Hippocampal neuron apoptosis damages cognitive ability. Methionine restriction (MR) can improve cognitive impairment. However, the effect of MR on hippocampal neuronal apoptosis induced by a high-fat diet (HFD) in middle-aged mice remains unclear. For 25 weeks, middle-aged mice (C57BL/6J) were given a control diet (CON, 0.86% methionine + 4.2% fat), a high-fat diet (HFD, 0.86% methionine + 24% fat), or an HFD + MR diet (HFMR, 0.17% methionine + 24% fat). The HT22 cells were used to establish the early apoptosis model induced by high glucose (HG). In vitro, the results showed that MR significantly improved cell viability, suppressed the generation of ROS, and rescued HT22 cell apoptosis in a gradient-dependent manner. In vivo, MR inhibited the damage and apoptosis of hippocampal neurons caused by a high-fat diet, reduced hippocampal oxidative stress, improved hippocampal glucose metabolism, relieved insulin resistance, and enhanced cognitive ability. Furthermore, MR could inhibit the overexpression of H19 and caspase-3 induced by HFD, HG, or H2O2 in vivo and in vitro, and promoted let-7a, b, e expression. These results indicate that MR can protect neurons from HFD-, HG-, or H2O2-induced injury and apoptosis by inhibiting H19.

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Section: Introductionmentioning

confidence: 99%

Methionine Restriction Improves Cognitive Ability by Alleviating Hippocampal Neuronal Apoptosis through H19 in Middle-Aged Insulin-Resistant Mice

Feng

Jiang

et al. 2022

Nutrients

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“…Transcriptomics is the study of all the RNA transcripts in an individual cell or family of cells, comprising both protein-coding messenger RNA (mRNA) and non-protein-coding RNAs, such as transfer RNA (tRNA), 150 ribosomal RNA (rRNA), 151 microRNA (miRNA), 88 , 152 - 157 enhancer RNA (eRNA), 158 small interfering RNA (siRNA), 159 P-element induced wimpy testis-interacting RNA (piRNA), 160 small nucleolar RNA (snoRNA), extracellular RNA (exRNA), small Cajal body-specific RNA (scaRNA), and long non-coding RNA (lncRNA). 161 Epigenomics is strictly tied to the transcriptome and is often seen as a subfield of transcriptomics. However, we leave our discussion of epigenomic biomarkers to the following section of this review.…”

Section: Transcriptomic Biomarkersmentioning

confidence: 99%

Progress Toward a Multiomic Understanding of Traumatic Brain Injury: A Review

et al. 2022

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Traumatic brain injury (TBI) is not a single disease state but describes an array of conditions associated with insult or injury to the brain. While some individuals with TBI recover within a few days or months, others present with persistent symptoms that can cause disability, neuropsychological trauma, and even death. Understanding, diagnosing, and treating TBI is extremely complex for many reasons, including the variable biomechanics of head impact, differences in severity and location of injury, and individual patient characteristics. Because of these confounding factors, the development of reliable diagnostics and targeted treatments for brain injury remains elusive. We argue that the development of effective diagnostic and therapeutic strategies for TBI requires a deep understanding of human neurophysiology at the molecular level and that the framework of multiomics may provide some effective solutions for the diagnosis and treatment of this challenging condition. To this end, we present here a comprehensive review of TBI biomarker candidates from across the multiomic disciplines and compare them with known signatures associated with other neuropsychological conditions, including Alzheimer’s disease and Parkinson’s disease. We believe that this integrated view will facilitate a deeper understanding of the pathophysiology of TBI and its potential links to other neurological diseases.

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“…Numerous lncRNAs are involved in multiple mechanisms in multiple cellular components. They interact with other RNA molecules or proteins, thereby modulating cellular signaling and epigenetic regulation [12][13][14][15] . Active enhancer sequence-derived eRNAs are considerably lengthy, i.e., more than 1 kilobase, and are responsible for enhancer-associated contributions 16,17 .…”

Section: Introductionmentioning

confidence: 99%

Molecular insights into regulatory RNAs in the cellular machinery

Yang,

Kim,

Yang

et al. 2024

Exp Mol Med

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It is apparent that various functional units within the cellular machinery are derived from RNAs. The evolution of sequencing techniques has resulted in significant insights into approaches for transcriptome studies. Organisms utilize RNA to govern cellular systems, and a heterogeneous class of RNAs is involved in regulatory functions. In particular, regulatory RNAs are increasingly recognized to participate in intricately functioning machinery across almost all levels of biological systems. These systems include those mediating chromatin arrangement, transcription, suborganelle stabilization, and posttranscriptional modifications. Any class of RNA exhibiting regulatory activity can be termed a class of regulatory RNA and is typically represented by noncoding RNAs, which constitute a substantial portion of the genome. These RNAs function based on the principle of structural changes through cis and/or trans regulation to facilitate mutual RNA‒RNA, RNA‒DNA, and RNA‒protein interactions. It has not been clearly elucidated whether regulatory RNAs identified through deep sequencing actually function in the anticipated mechanisms. This review addresses the dominant properties of regulatory RNAs at various layers of the cellular machinery and covers regulatory activities, structural dynamics, modifications, associated molecules, and further challenges related to therapeutics and deep learning.

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Discoveries for Long Non-Coding RNA Dynamics in Traumatic Brain Injury

Cited by 9 publications

References 93 publications

Methionine Restriction Improves Cognitive Ability by Alleviating Hippocampal Neuronal Apoptosis through H19 in Middle-Aged Insulin-Resistant Mice

Methionine Restriction Improves Cognitive Ability by Alleviating Hippocampal Neuronal Apoptosis through H19 in Middle-Aged Insulin-Resistant Mice

Progress Toward a Multiomic Understanding of Traumatic Brain Injury: A Review

Molecular insights into regulatory RNAs in the cellular machinery

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