Discovery and characterization of naturally occurring potent inhibitors of catechol-<i>O</i>-methyltransferase from herbal medicines

Zhao, Di; Fan, Yufan; Wang, Fangyuan; Hou, Fan-Bin; Gonzalez, Frank J.; Li, Shi-Yang; Wang, Ping; Xia, Yangliu; Ge, Guang-Bo; Yang, Ling

doi:10.1039/d0ra10425f

Cited by 8 publications

(3 citation statements)

References 48 publications

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“…293T-Nrf2-luc cell lines were first seeded in 96-well plates at a density of 8 × 10 3 cells per well and grown overnight. Baicalin and iso-dihydromyricetin were prepared in our laboratory (Xiong et al, 2021;Zhao et al, 2021). Propofol (Fresenius Kabi, China), midazolam (Enhua, China), sufentanil (Humanwell, China), remifentanil (Humanwell, China), dexmedetomidine (Enhua, China), ketamine (Hengrui, China), dopamine (Fenghe, China),norepinephrine (Fenghe, China), epinephrine (Fenghe, China), diazepam (Xinyi, China), estazolam (Zhongxin, China), alprazolam (Enhua, China), rocuronium (Xianju, China), wogonin, liquiritin, anhydroicaritin, silybin A-SILYBIN-A, isoginkgetin, wogonoside, baicalein, scutellarein, scutellarin, hyperoside, liquiritigenin, glutamate, myricetin, dihydromyricetin, procyanidin (They were all purchased from Chengdu Purfield Biotechnology Co., Ltd. China), Baicalin and iso-dihydromyricetin were added at the final concentration of 10 μM, while sulforaphane (Sigma-Aldrich, United States) was used as a positive control (Russo et al, 2018).…”

Section: Nrf2 Reporter Assaymentioning

confidence: 99%

Midazolam Ameliorates Acute Liver Injury Induced by Carbon Tetrachloride via Enhancing Nrf2 Signaling Pathway

et al. 2022

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Oxidative stress contributes greatly to initiation and progression of liver injury. Activation of nuclear-factor erythroid 2-related factor 2 (Nrf2) has been considered as an attractive strategy for preventing and treating the oxidative damage related to liver injury. This study aimed to find an efficacious agent to activate Nrf2/HO-1 signaling pathway from clinically used therapeutic agents and to characterize the usefulness for preventing and treating CCl4-induced acute liver injury. For this purpose, a series of clinically used therapeutic agents were collected and their activation potentials on Nrf2 were assayed by using 293T-Nrf2-luc cell line. Among all tested therapeutic agents, midazolam was found with good Nrf2 activation effect and this agent could significantly ameliorate CCl4-induced damage to HepG2 cells. In vivo animal tests showed that pretreatment with midazolam reduced the liver pathological tissue damage and the serum levels of ALT and AST in CCl4-induced liver injury mice. Further investigations showed that midazolam could strongly up-regulate the expression of both Nrf2 and HO-1 in the mice liver, accompanied by increasing of the levels of antioxidant enzyme SOD and reducing the production of MDA, as well as reducing the pro-inflammatory cytokines (IL-6, TNF-α) secretion. Collectively, our results clearly demonstrate that midazolam can ameliorate CCl4-induced acute liver injury and oxidative stress via activating the Nrf2 signaling pathway.

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Section: Nrf2 Reporter Assaymentioning

confidence: 99%

Midazolam Ameliorates Acute Liver Injury Induced by Carbon Tetrachloride via Enhancing Nrf2 Signaling Pathway

et al. 2022

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“…Similarly, baicalein administration is found to restore striatal dopamine content, decrease dopaminergic neuron degeneration in SN, ameliorate oxidative stress, neuroinflammation, α‐synuclein aggregation and autophagy impairment, as well as inhibit MAO‐B activity and improve motor deficits in PD mice and rats (Hu et al, 2016; Hung et al, 2016; Mu et al, 2011; Song et al, 2021). Further, in silico and in vitro studies demonstrated baicalein to be a potent inhibitor of COMT (Zhao et al, 2021). Research from the last few years highlighted the therapeutic efficacy of luteolin to reduce AD and PD symptoms in various cellular and experimental studies.…”

Section: Phyto‐compounds and Their Neuroprotective Effects In Ad And ...mentioning

confidence: 99%

Therapeutic considerations of bioactive compounds in Alzheimer's disease and Parkinson's disease: Dissecting the molecular pathways

Phukan,

Roy,

Gahatraj

et al. 2023

Phytotherapy Research

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Leading neurodegenerative diseases Alzheimer's disease (AD) and Parkinson's disease (PD) are characterized by the impairment of memory and motor functions, respectively. Despite several breakthroughs, there exists a lack of disease‐modifying treatment strategies for these diseases, as the available drugs provide symptomatic relief and bring along side effects. Bioactive compounds are reported to bear neuroprotective properties with minimal toxicity, however, a detailed elucidation of their modes of neuroprotection is lacking. The review elucidates the neuroprotective mechanism(s) of some of the major phyto‐compounds in pre‐clinical and clinical studies of AD and PD to understand their potential in combating these diseases. Curcumin, eugenol, resveratrol, baicalein, sesamol and so on have proved efficient in countering the pathological hallmarks of AD and PD. Curcumin, resveratrol, caffeine and so on have reached the clinical phases of these diseases, while aromadendrin, delphinidin, cyanidin and xanthohumol are yet to be extensively explored in pre‐clinical phases. The review highlights the need for extensive investigation of these compounds in the clinical stages of these diseases so as to utilize their disease‐modifying abilities in the real field of treatment. Moreover, poor pharmacokinetic properties of natural compounds are constraints to their therapeutic yields and this review suggests a plausible contribution of nanotechnology in overcoming these limitations.

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“…14,15 Recent reports have highlighted a variety of natural compounds showing inhibition of COMT activity. For example, herbal purified components (e.g., rutin, quercetin, baicalein, myricetin, and celastrol) successively discovered and isolated from a variety of medicinal plants were found to have COMT inhibitory activity, 16,17 which inspired the search for novel COMT inhibitors. 18 These natural inhibitors have gained increasing popularity for their broad applicability, safety profile, and reduced side effects compared to their synthetic counterparts.…”

Section: Introductionmentioning

confidence: 99%

Bioactive components and mechanisms of Pu-erh tea in improving levodopa metabolism in rats through COMT inhibition

Zhou,

Li,

Wang

et al. 2024

Food Funct.

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Discovery and characterization of naturally occurring potent inhibitors of catechol-O-methyltransferase from herbal medicines

Abstract: Discovery and characterization of natural human catechol-O-methyltransferase (hCOMT) inhibitors for Parkinson's disease treatment.

Cited by 8 publications

References 48 publications

Midazolam Ameliorates Acute Liver Injury Induced by Carbon Tetrachloride via Enhancing Nrf2 Signaling Pathway

Midazolam Ameliorates Acute Liver Injury Induced by Carbon Tetrachloride via Enhancing Nrf2 Signaling Pathway

Therapeutic considerations of bioactive compounds in Alzheimer's disease and Parkinson's disease: Dissecting the molecular pathways

Bioactive components and mechanisms of Pu-erh tea in improving levodopa metabolism in rats through COMT inhibition

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