Discovery, diversity and evolution of novel coronaviruses sampled from rodents in China

Wang, Wen; Lin, Xian; Guo, Wen; Zhou, Run; Wang, Miao Ruo; Wang, Cai Qiao; Ge, Shuang; Mei, Sheng Hua; Li, Ming Hui; Shī, Mǎng; Holmes, Edward C.; Zhāng, Yǒng Zhèn

doi:10.1016/j.virol.2014.10.017

Cited by 124 publications

(134 citation statements)

References 47 publications

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“…Unlike other alpha-and betacoronavirus species, BetaCoV1 and the related mouse hepatitis virus (MHV) and HCoV-HKU1 do not seem to have ancestral links to bats. Several recent descriptions of novel BetaCoV1 members or relatives in rodents suggest them as primordial hosts (Hu et al, 2017;Lau et al, 2015;Wang et al, 2015). HCoV-OC43 was found to have tropism for neural cells in vitro and in experimentally infected mice, resembling MHV (Arbour et al, 1999;Jacomy et al, 2006).…”

Section: Hcov-oc43mentioning

confidence: 95%

“…There are no conspecific virus sequences from any other animal species. However, as HCoV-HKU1 is a sister taxon to MHV and rat sialodacryoadenitis virus, and together with these stands in sister relationship to BetaCoV1 with its basal rodent-associated viruses, a primordial association with rodent hosts may be considered (Hu et al, 2017;Lau et al, 2015;Wang et al, 2015;Woo et al, 2005).…”

Section: Hcov-hku1mentioning

confidence: 99%

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Hosts and Sources of Endemic Human Coronaviruses

Corman

Muth

Niemeyer

et al. 2018

Advances in Virus Research

920

835

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The four endemic human coronaviruses HCoV-229E, -NL63, -OC43, and -HKU1 contribute a considerable share of upper and lower respiratory tract infections in adults and children. While their clinical representation resembles that of many other agents of the common cold, their evolutionary histories, and host associations could provide important insights into the natural history of past human pandemics. For two of these viruses, we have strong evidence suggesting an origin in major livestock species while primordial associations for all four viruses may have existed with bats and rodents. HCoV-NL63 and -229E may originate from bat reservoirs as assumed for many other coronaviruses, but HCoV-OC43 and -HKU1 seem more likely to have speciated from rodent-associated viruses. HCoV-OC43 is thought to have emerged from ancestors in domestic animals such as cattle or swine. The bovine coronavirus has been suggested to be a possible ancestor, from which HCoV-OC43 may have emerged in the context of a pandemic recorded historically at the end of the 19th century. New data suggest that HCoV-229E may actually be transferred from dromedary camels similar to Middle East respiratory syndrome (MERS) coronavirus. This scenario provides important ecological parallels to the present prepandemic pattern of host associations of the MERS coronavirus.

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Section: Hcov-oc43mentioning

confidence: 95%

Section: Hcov-hku1mentioning

confidence: 99%

Hosts and Sources of Endemic Human Coronaviruses

Corman

Muth

Niemeyer

et al. 2018

Advances in Virus Research

920

835

View full text Add to dashboard Cite

show abstract

“…EF203064 to EF203067) are marked by "*". backbone replaced by a betaCoV S gene (Lau et al, 2007;Wang et al, 2015a). Furthermore, pairwise comparison of SeACoV genomic sequence with HKU2 indicated that the most dissimilar region was in the S gene, particularly, in the extreme NTD (aa 1-238).…”

Section: Complete Genomic Sequence Of the Emergent Seacov Revealed Itmentioning

confidence: 99%

“…However, analysis of the phylogenetic tree constructed based on the S genes (Fig. 4B) indicated that these six HKU2-related CoV strains along with a newly identified rat alphaCoV, LRNV (Wang et al, 2015a), formed a separate lineage clustered within the betaCoVs. The previous studies have suggested that HKU2 and the related LRNV probably resulted from an ancient recombination event with an alphaCoV genomic Fig.…”

Section: Complete Genomic Sequence Of the Emergent Seacov Revealed Itmentioning

confidence: 99%

Discovery of a novel swine enteric alphacoronavirus (SeACoV) in southern China

Pan

Tian

Qin

et al. 2017

Veterinary Microbiology

204

302

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Outbreaks of diarrhea in newborn piglets without detection of transmissible gastroenteritis virus (TGEV), porcine epidemic diarrhea virus (PEDV) and porcine deltacoronavirus (PDCoV), have been recorded in a pig farm in southern China since February 2017. Isolation and propagation of the pathogen in cell culture resulted in discovery of a novel swine enteric alphacoronavirus (tentatively named SeACoV) related to the bat coronavirus HKU2 identified in the same region a decade ago. Specific fluorescence signal was detected in Vero cells infected with SeACoV by using a positive sow serum collected in the same farm, but not by using TGEV-, PEDV- or PDCoV-specific antibody. Electron microscopy observation demonstrated that the virus particle with surface projections was 100-120nm in diameter. Complete genomic sequencing and analyses of SeACoV indicated that the extreme amino-terminal domain of the SeACoV spike (S) glycoprotein structurally similar to the domain 0 of the alphacoronavirus NL63, whereas the rest part of S structurally resembles domains B to D of the betacoronavirus. The SeACoV-S domain 0 associated with enteric tropism had an extremely high variability, harboring 75-amino-acid (aa) substitutions and a 2-aa insertion, compared to that of HKU2, which is likely responsible for the extended host range or cross-species transmission. The isolated virus was infectious in pigs when inoculated orally into 3-day-old newborn piglets, leading to clinical signs of diarrhea and fecal virus shedding. These results confirmed that it is a novel swine enteric coronavirus representing the fifth porcine coronavirus.

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“…Although bats, rodents, and birds act as the natural reservoir species for many coronaviruses (1)(2)(3), host range expansion into other species has been prevalent over the course of their evolutionary history. Known human coronaviruses likely originated as zoonotic pathogens that underwent host range expansion.…”

Section: Introductionmentioning

confidence: 99%

Coronavirus Host Range Expansion and Middle East Respiratory Syndrome Coronavirus Emergence: Biochemical Mechanisms and Evolutionary Perspectives

Peck¹,

Burch²,

Heise

et al. 2015

Annu. Rev. Virol.

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Coronaviruses have frequently expanded their host range in recent history, with two events resulting in severe disease outbreaks in human populations. Severe acute respiratory syndrome coronavirus (SARS-CoV) emerged in 2003 in Southeast Asia and rapidly spread around the world before it was controlled by public health intervention strategies. The 2012 Middle East respiratory syndrome coronavirus (MERS-CoV) outbreak represents another prime example of virus emergence from a zoonotic reservoir. Here, we review the current knowledge of coronavirus cross-species transmission, with particular focus on MERS-CoV. MERS-CoV is still circulating in the human population, and the mechanisms governing its cross-species transmission have been only partially elucidated, highlighting a need for further investigation. We discuss biochemical determinants mediating MERS-CoV host cell permissivity, including virus spike interactions with the MERS-CoV cell surface receptor dipeptidyl peptidase 4 (DPP4), and evolutionary mechanisms that may facilitate host range expansion, including recombination, mutator alleles, and mutational robustness. Understanding these mechanisms can help us better recognize the threat of emergence for currently circulating zoonotic strains.

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Discovery, diversity and evolution of novel coronaviruses sampled from rodents in China

Cited by 124 publications

References 47 publications

Hosts and Sources of Endemic Human Coronaviruses

Hosts and Sources of Endemic Human Coronaviruses

Discovery of a novel swine enteric alphacoronavirus (SeACoV) in southern China

Coronavirus Host Range Expansion and Middle East Respiratory Syndrome Coronavirus Emergence: Biochemical Mechanisms and Evolutionary Perspectives

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