2021
DOI: 10.4155/fmc-2021-0272
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Discovery of a Novel Class of Small-Molecule Antibacterial Agents Against Staphylococcus Aureus

Abstract: Background: With constantly increasing resistance against the known antibiotics, the search for novel antibacterial compounds is a challenge. The number of synthetic antibacterial agents is limited. Materials & methods: We discovered novel small-molecule antibacterial agents that are accessible via a simple two-step procedure. The evaluation against Staphylococcus aureus showed antibacterial effects depending on the substituent positioning at the residues of the molecular scaffold. Additionally, we investi… Show more

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Cited by 2 publications
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