Discovery of a novel water-soluble, rapid-release triptolide prodrug with improved drug-like properties and high efficacy in human acute myeloid leukemia

Kang, Di; Peng, Xiang; Song, Yi; Liu, Yan; Wang, Dan; Zhu, Xun; Wang, Junwei; Hu, Lihong

doi:10.1016/j.ejmech.2022.114694

Cited by 6 publications

(2 citation statements)

References 34 publications

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“…f. Triptolide has a broad range of pharmacological effects on autoimmune diseases, including rheumatoid arthritis ( Li et al, 2022a ), systemic lupus erythematosus ( Zhang et al, 2022a ), ankylosing spondylitis ( Ji et al, 2022 ), and so on. Due to poor water solubility (0.017 mg/ml) and severe toxicity including excessive immune responses, its clinical application is greatly limited ( Ding et al, 2017 ), and several strategies has been applied to reduce its toxicity and to improve its solubility ( Kang et al, 2022a ; Zhang et al, 2022b ; Rao et al, 2022 ).…”

Section: Natural Products Undergoing Clinical Evaluation In Pancreati...mentioning

confidence: 99%

The therapeutic potential of natural products for treating pancreatic cancer

Wang

Zhang

et al. 2022

Front. Pharmacol.

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Pancreatic cancer is one of the most malignant tumors of the digestive tract, with the poor prognosis and low 5-year survival rate less than 10%. Although surgical resection and chemotherapy as gemcitabine (first-line treatment) has been applied to the pancreatic cancer patients, the overall survival rates of pancreatic cancer are quite low due to drug resistance. Therefore, it is of urgent need to develop alternative strategies for its treatment. In this review, we summarized the major herbal drugs and metabolites, including curcumin, triptolide, Panax Notoginseng Saponins and their metabolites etc. These compounds with antioxidant, anti-angiogenic and anti-metastatic activities can inhibit the progression and metastasis of pancreatic cancer. Expecting to provide comprehensive information of potential natural products, our review provides valuable information and strategies for pancreatic cancer treatment.

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Section: Natural Products Undergoing Clinical Evaluation In Pancreati...mentioning

confidence: 99%

The therapeutic potential of natural products for treating pancreatic cancer

Wang

Zhang

et al. 2022

Front. Pharmacol.

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“…23 In some cases, however, higher release speed is desired, e.g., rapid drug release in gastrointestinal tract triggered by environmental variations. [24][25][26] In our previous work, shape memory effect has been introduced to porous materials. 27 Relative to traditional stimuli-responsive materials, porous shape memory polymers are excellent candidate for rapid release of drugs since they exhibit exciting features.…”

Section: Introductionmentioning

confidence: 99%