Discovery of an arsenic and mercury co-elevation in the Midwest United States using reference laboratory data

Day, Patrick L.; Nelson, Erik J.; Bluhm, Amy M.; Wood‐Wentz, Christina M.; Jannetto, Paul J.

doi:10.1016/j.envpol.2019.113049

Cited by 6 publications

(1 citation statement)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The timing of urine sample collection was not systematically recorded; however, the majority of urine samples were collected in the morning of each visit. We also did not speciate As or Hg metabolites which can vary proportionally by exposure sources, such as diet or geographic factors [69,70]. Toxicokinetic differences in metal and metalloid distribution, metabolism, and excretion also influence the selection of metal biomatrix and measured concentrations [71].…”

Section: Discussionmentioning

confidence: 99%

Prenatal Metal Exposures and Associations with Kidney Injury Biomarkers in Children

Politis

Yao

Gennings

et al. 2022

Toxics

View full text Add to dashboard Cite

Prenatal exposure to arsenic (As), cadmium (Cd), mercury (Hg), and lead (Pb) may be nephrotoxic, yet limited studies have examined subclinical kidney injury biomarkers in children. We assessed whether metal exposure in the second trimester (2T), a crucial time of kidney development, is associated with altered urine kidney injury and function biomarkers in preadolescent children. Analyses included 494 children participating in a birth cohort study in Mexico City. Concentrations of As, Cd, and Pb were measured from pregnant women in 2T blood and urine, and Hg in urine only. Kidney biomarkers were measured from children in urine at age 8–12 years. We assessed the associations between individual metals and (1) kidney biomarkers using linear regression and (2) a multi-protein kidney mixture using weighted quantile sum (WQS) regression. Associations of separate urine and blood metal mixtures with individual kidney biomarkers were assessed via WQS. Within the multi-protein mixture, the association with increased urinary As was predominated by urine alpha-1-microglobulin (A1M), interferon gamma-induced protein 10 (IP10), and fatty acid binding protein 1; the association with increased urinary Cd was predominated by A1M, clusterin, and albumin. The urine metal mixture was associated with increased albumin (0.23 ng/mL; 95% confidence interval (CI): 0.10, 0.37), IP10 (0.15 ng/mL; 95% CI: 0.02, 0.28), and cystatin C (0.17 ng/mL; 95% CI: 0.04, 0.31); these associations were mainly driven by urinary As and Cd. We observed null associations between prenatal blood or urine metal mixtures and estimated glomerular filtration rate. Higher prenatal urinary metals, individually and as a mixture were associated with altered kidney injury biomarkers in children. Further research and longer participant follow-up are required to ascertain the risk of kidney disease later in life.

show abstract

Section: Discussionmentioning

confidence: 99%