Discovery of Bioactive Compounds by the UIC-ICBG Drug Discovery Program in the 18 Years Since 1998

Zhang, Hongjie; Li, Wan Fei; Fong, Harry H. S.; Soejarto, Djaja D.

doi:10.3390/molecules21111448

Cited by 10 publications

(9 citation statements)

References 43 publications

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“…Two diterpenes, E-phytol (20) [IC50: 8.5 μM (PoW); 11.5μM (Dd2)], and 6E-geranylgeraniol-19-oic acid (21) [IC50: 12.9μM (PoW); 15.6μM (Dd2)] were shown to be the most active compounds in their test system ( Figure 6). …”

Section: Asclepiadaceae Familymentioning

confidence: 99%

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Antimalarial Activity of Plant Metabolites

Pan¹,

Xu²,

Shi³

et al. 2018

Preprint

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Malaria, as a major global health problem, continues to affect a large number of people each year, especially those in the developing countries. Effective drug discovery is still one of the main efforts to control malaria. As natural products are still considered as a key source for discovery and development of therapeutic agents, we have evaluated more than 2,000 plant extracts against Plasmodium falciparum. As a result, we discovered dozens of plant leads that displayed antimalarial activity. Our phytochemical study of some of these plant extracts led to identification of several potent antimalarial compounds. The prior comprehensive review article entitled "Antimalarial activity of plant metabolites" by Schwikkard and Van Heerden (2002) reported structures of plant-derived compounds with antiplasmodial activity and covered literature up to the year 2000. As a continuation of this effort, the present review covers the antimalarial compounds isolated from plants, including marine plants, reported in the literatures from 2001 to the end of 2017. During the span of the last 17 years, 175 antiplasmodial compounds were discovered from plants. These active compounds are organized in our review article according to their plant families. In addition, we also include ethnobotanical information of the antimalarial plants discussed.

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Section: Asclepiadaceae Familymentioning

confidence: 99%

“…Several of these plant leads were investigated further to uncover their antimalarial constituents. Phytochemical separation of these plant leads guided by bioassay led to the identification of 10 new and 13 known active compounds [21]. Some of these compounds demonstrated potent antimalarial activity [2229].…”

Section: Introductionmentioning

confidence: 99%

Antimalarial Activity of Plant Metabolites

Pan¹,

Xu²,

Shi³

et al. 2018

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…Several of these plant leads were investigated further to uncover their antimalarial constituents. Phytochemical separation of these plant leads guided by bioassays led to the identification of ten new and 13 known active compounds [ 21 ]. Some of these compounds demonstrated potent antimalarial activity [ 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

Antimalarial Activity of Plant Metabolites

Pan

Shi

et al. 2018

IJMS

Self Cite

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Malaria, as a major global health problem, continues to affect a large number of people each year, especially those in developing countries. Effective drug discovery is still one of the main efforts to control malaria. As natural products are still considered as a key source for discovery and development of therapeutic agents, we have evaluated more than 2000 plant extracts against Plasmodium falciparum. As a result, we discovered dozens of plant leads that displayed antimalarial activity. Our phytochemical study of some of these plant extracts led to the identification of several potent antimalarial compounds. The prior comprehensive review article entitled “Antimalarial activity of plant metabolites” by Schwikkard and Van Heerden (2002) reported structures of plant-derived compounds with antiplasmodial activity and covered literature up to the year 2000. As a continuation of this effort, the present review covers the antimalarial compounds isolated from plants, including marine plants, reported in the literature from 2001 to the end of 2017. During the span of the last 17 years, 175 antiplasmodial compounds were discovered from plants. These active compounds are organized in our review article according to their plant families. In addition, we also include ethnobotanical information of the antimalarial plants discussed.

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“…In addition, the most effective treatment for malaria caused by P. falciparum infection is possibly the use of artemisininin in conjunction with other drugs known as artemisinin-based combination therapy (ACT) ( WHO, 2017 ). Zhang et al (2016) examined the effects of more than 2000 plant extracts on two different strains of P. falciparum . Most of these plants displayed significant antimalarial activity.…”

Section: Antimalarial Activities Of Natural Productsmentioning

confidence: 99%

Botanical candidates from Saudi Arabian flora as potential therapeutics for Plasmodium infection

Al‐Quraishy

Abdel-Maksoud

Al-Shaebi

et al. 2021

Saudi Journal of Biological Sciences

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Malaria is a lethal parasitic disease affecting over two hundred million people worldwide and kills almost half a million people per year. Until now, there is no curative treatment for this disease that has a substantial morbidity. The available chemotherapeutic agents are unable to completely control the infection with the continuous appearance of drug resistance. Consequently, the search for new therapeutic agents with high safety profiles and low side effects is of paramount importance. Several natural products have been investigated and proven to have antimalarial effects either in vivo or in vitro . A large number of plants have been studied globally for their antimalarial activities. However, studies that have been conducted in this field in Saudi Arabia are not enough. This article presents global and local research on the need for novel natural antimalarial agents with a particular emphasis on studies involving plants from Saudi Arabian flora.

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Discovery of Bioactive Compounds by the UIC-ICBG Drug Discovery Program in the 18 Years Since 1998

Cited by 10 publications

References 43 publications

Antimalarial Activity of Plant Metabolites

Antimalarial Activity of Plant Metabolites

Antimalarial Activity of Plant Metabolites

Botanical candidates from Saudi Arabian flora as potential therapeutics for Plasmodium infection

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