Discovery of Bioactive Natural Products from Bacillus Species: Chemistry, Biosynthesis and Biological Activities

Surovy, Musrat Zahan; Rahman, Shahinoor; Dame, Zerihun T.; Islam, Tofazzal

doi:10.1007/978-3-030-85465-2_3

Cited by 5 publications

(7 citation statements)

References 232 publications

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“…These organisms commonly produce isocoumarins, lipopeptides, polyketides, aminoglycoside, aminopolyol, phospholipids, phosphon oligopeptide, and terpenoids [57,58]. Similarly, the most important antibiotics rifamycin and gramicidin are reported from Streptomyces and Bacillus [59].…”

Section: Bacterial Metabolitesmentioning

confidence: 99%

Antimicrobial and anticancer potential of soil bacterial metabolites - a comprehensive and updated review

Kumar¹,

Kumaresan²

2023

J App Biol Biotech

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The majority of natural products currently used in the medical field are derived from microbial or plant sources. The bioactive compounds derived from natural sources exhibit tremendous structural and chemical diversity. According to previous research, only a small percentage of the world's plant and microbial diversity has been examined for bioactivities. The compounds originating from secondary metabolites of microorganisms are more useful for the development of novel drugs due to their biological friendliness and drug-likeness than any other compounds. Thus, recent research suggests that microorganisms obtained from diverse habitats and natural resources offer various bioactive secondary metabolites with incredibly wider chemical entities, hopefully, an alternative remedy for many diseases. Soil bacteria are capable of producing a variety of natural bioactive compounds for the treatment of various diseases. The three genera Bacillus spp., Streptomyces spp., and Pseudomonas spp. have been the prime focus to produce different types of antibiotics. However, to date, there are no reviews that evaluated the antimicrobial and anticancer properties of soil bacterial metabolites. Hence, the current review aimed to assess the antimicrobial and anticancer potential of soil bacterial metabolites.

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Section: Bacterial Metabolitesmentioning

confidence: 99%

Antimicrobial and anticancer potential of soil bacterial metabolites - a comprehensive and updated review

Kumar¹,

Kumaresan²

2023

J App Biol Biotech

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“…Theree bacterial strains -B. subtilis BTS-3 (NCBI accession WOVJ00000000), B. velezensis BTS-4 (NCBI accession WOVK00000000) and B. velezensis BTLK6A (NCBI accession WOYD00000000) -were used in this study [23]. BTS-3 and BTS-4 bacterial strains were isolated from the 'Rangabinni' rice seeds, and BTLK6A from the 'Kanchan' wheat seeds of Bangladesh [23,44,46,47]. All Bacillus strains were stored as pure cultures in 20% glycerol at -20 °C.…”

Section: Bacterial Strains and Culture Conditionsmentioning

confidence: 99%

Suppressive Effects of Volatile Compounds from <em>Bacillus </em>spp. on <em>Magnaporthe oryzae Triticum</em> (MoT) Pathotype, Causal Agent of Wheat Blast

Surovy¹,

Rahman²,

Rostás³

et al. 2023

Preprint

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Magnaporthe oryzae Triticum (MoT) pathotype is the causal agent of wheat blast, which has caused significant economic losses and threatens wheat production in South America, Asia and Africa. Three bacterial strains from rice and wheat seeds (B. subtilis BTS-3, B. velezensis BTS-4, and B. velezensis BTLK6A) were used to explore the antifungal effects of volatile organic compounds (VOCs) of Bacillus spp. as a potential biocontrol mechanism against MoT. All bacterial treatments significantly inhibited both mycelial growth and sporulation of MoT in vitro. We found that this inhibition was caused by Bacillus VOCs in a dose-dependent manner. In addition, biocontrol assays using detached wheat leaves infected with MoT showed reduced leaf lesions and sporulation compared to the untreated control. VOCs from B. velezensis BTS-4 alone or a consortium (mixture of B. subtilis BTS-3, B. velezensis BTS-4, and B. velezensis BTLK6A) treatments consistently suppressed MoT in vitro and in vivo. Compared to the untreated control, VOCs from BTS-4 and Bacillus consortium reduced MoT lesions in vivo by 85% and 81.25%, respectively. A total of thirty-nine VOCs (from 9 different VOC groups) from 4 Bacillus treatments were identified by gas chromatography-mass spectrometry (GC-MS), of which 11 were produced in all Bacillus treatments. Alcohols, fatty acids, ketones, aldehydes, and S-containing compounds were detected in all four bacterial treatments. In vitro assays using pure VOCs revealed that hexanoic acid, 2-methylbutanoic acid, and phenylethyl alcohol are potential VOCs emitted by Bacillus spp. that are suppressive for MoT. The minimum inhibitory concentrations for MoT sporulation were 250 mM for phenylethyl alcohol and 500 mM for 2-methylbutanoic acid and hexanoic acid. Therefore, our results indicate that VOCs from Bacillus spp. are effective compounds to suppress the growth and sporulation of MoT. Understanding the MoT sporulation reduction mechanisms by Bacillus VOCs may provide novel options to manage the further spread of wheat blast by spores.

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“…On the one hand, Bacillus species are natural residents of the rhizosphere or phyllosphere of plants, and are considered beneficial to the environment 11 ; on the other hand, Bacillus species can produce secondary metabolites (including lipopeptides, polyketides, polypeptides, etc.) to inhibit plant pathogens or induce plant systemic resistance 12 . Among these metabolites, lipopeptides (such as surfactin, iturin, and fengycin) secreted by Bacillus are not only biodegradable, non‐toxic, highly stable, and eco‐friendly biomolecules, 13 but also have a wide range of applications in plant disease management and food preservation 13,14 .…”

Section: Introductionmentioning

confidence: 99%

“…to inhibit plant pathogens or induce plant systemic resistance. 12 Among these metabolites, lipopeptides (such as surfactin, iturin, and fengycin) secreted by Bacillus are not only biodegradable, non-toxic, highly stable, and eco-friendly biomolecules, 13 but also have a wide range of applications in plant disease management and food preservation. 13,14 For example, surfactin, iturin, and fengycin are the main lipopeptides that have been applied to reduce preharvest or postharvest losses in fruits and vegetables such as apples, 15 lemons, strawberries, 16 and Chinese cabbage, 17 because they have strong broad-spectrum antimicrobial activity.…”

Section: Introductionmentioning

confidence: 99%

Isolation, structural characterization and sporicidal properties of Baelezcin A, a novel cyclic lipopeptide from Bacillus velezensis SJ100083 against gray mold

Yuan

Zhou

et al. 2023

J Sci Food Agric

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Background Postharvest gray mold induced by Botrytis cinerea seriously affects cherry quality, resulting in huge economic losses. The aim of this study was to isolate and purify a novel antifungal compound from the endophytic Bacillus velezensis SJ100083 of cherries to prevent postharvest gray mold. Results In this study, Baelezcin A, extracted and purified from Bacillus velezensis SJ100083, was found effective in suppressing gray mold on cherries. Furthermore, the structure of Baelezcin A was identified as a novel cyclic lipopeptide with molecular formula of C52H91N7O13 through ultra‐high‐performance liquid chromatography quadrupole Orbitrap high‐resolution mass spectrometry (UHPLC‐Q‐Orbitrap‐HRMS) and nuclear magnetic resonance (NMR). Baelezcin A treatment at 25 mg L−1 significantly decreased the disease incidence and severity of cherry gray mold, the antifungal mechanism of which was attributed to the accumulation of reactive oxygen species within the spores and the leakage of mycelium cytoplasmal contents, resulting in a low rate of spore germination. Moreover, it was proven to be biologically safe within a certain range by MTT assays. Conclusion Our study demonstrated that Baelezcin A from the culture of Bacillus velezensis SJ100083 may be a promising fruit preservative for controlling postharvest gray mold caused by Botrytis cinerea. © 2023 Society of Chemical Industry.

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Discovery of Bioactive Natural Products from Bacillus Species: Chemistry, Biosynthesis and Biological Activities

Cited by 5 publications

References 232 publications

Antimicrobial and anticancer potential of soil bacterial metabolites - a comprehensive and updated review

Antimicrobial and anticancer potential of soil bacterial metabolites - a comprehensive and updated review

Suppressive Effects of Volatile Compounds from <em>Bacillus </em>spp. on <em>Magnaporthe oryzae Triticum</em> (MoT) Pathotype, Causal Agent of Wheat Blast

Isolation, structural characterization and sporicidal properties of Baelezcin A, a novel cyclic lipopeptide from Bacillus velezensis SJ100083 against gray mold

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