Discovery of ergosterol derivative from Aspergillus sp. TJ507 that protects against hepatic ischemia/reperfusion injury

Hu, Hong; Li, Yanhui; Shi, Zhengyi; Zhao, Xiangli; Lan, Xueqi; Wu, Meng; Tang, Bo; Zhang, Yeting; Huang, Xinye; Bu, Pengfei; Guo, Yi; Tan, Xiaosheng; Qi, Changxing; Zhang, Yonghui

doi:10.1016/j.bioorg.2023.106530

Cited by 4 publications

(4 citation statements)

References 20 publications

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“…Body temperature was maintained at 32 °C with a warming pad. Mice in the 3 -pretreated group were given 3 once a day for 3 days (10 mg/kg, intraperitoneally), and the same operation was performed 1 h after injecting 3 on the last day . The negative control mice underwent the same process except for hepatic ischemia.…”

Section: Methodsmentioning

confidence: 99%

“…Natural products are an important source of agents against IRI-associated diseases. For example, the diterpene dictyol C showed neuroprotective effects against cerebral IRI, and anethole, baicalin, 5α-stigmast-3,6-dione, and plumbagin displayed significant hepatoprotective activities in the hepatic IRI mouse model. Indole alkaloids are broadly distributed in marine and terrestrial sources − and display a variety of bioactivities including antitumor, cytotoxic, anti-inflammatory, antimalarial, antimicrobial, and antiviral activity .…”

mentioning

confidence: 99%

“…A hepatic vessel-interrupted mice model can be effectively used to evaluate potential therapeutic drugs for hepatic IRI . In this study, we employed the liver vessel interruption-induced ischemia/reperfusion injury murine model to comprehensively evaluate the protective effects of 3 against hepatic IRI . To evaluate the severity of hepatic injury, we measured the levels of three essential enzymes: alanine aminotransferase (ALT), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH), which served as reliable indicators of liver damage .…”

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confidence: 99%

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Bioactive Indole Alkaloid from Aspergillus amoenus TJ507 That Ameliorates Hepatic Ischemia/Reperfusion Injury

et al. 2023

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Hepatic ischemia/reperfusion injury (IRI) is a major factor contributing to the failure of hepatic resection and liver transplantation. As part of our ongoing investigation into bioactive compounds derived from fungi, we isolated eight indole alkaloids (1–8) from the endophytic fungus Aspergillus amoenus TJ507. Among these alkaloids, one previously undescribed compound, amoenamide D (1), was identified. The planar structure of 1 was elucidated by extensive spectroscopic analysis, including HRESIMS and NMR spectra. The absolute configuration of 1 was elucidated by using electronic circular dichroism calculations. Notably, in the CoCl2-induced hepatocyte damage model, notoamide Q (3) exhibited significant anti-hypoxia injury activity. Furthermore, in a murine hepatic ischemia/reperfusion injury model, treatment with 3 prevents IRI-induced liver damage and hepatocellular apoptosis. Consequently, 3 might serve as a potential lead compound to prevent hepatic ischemia/reperfusion injury.

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Section: Methodsmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Bioactive Indole Alkaloid from Aspergillus amoenus TJ507 That Ameliorates Hepatic Ischemia/Reperfusion Injury

et al. 2023

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“…After which, only about 11 members of this skeleton have been reported − (Figure S2). In our continuous studies on bioactive molecules from fungi, − nine new sesquiterpene alkaloids, namely eurochevalierines A – I ( 1 – 9 ) were separated from the rice cultures of Penicillium sp. HZ-5, acquired from Hypericum wilsonii N. Robson (Figure ).…”

Section: Introductionmentioning

confidence: 99%

Eurochevalierines A–I, Sesquiterpene Alkaloid Hybrids with Anti-Triple Negative Breast Cancer Activity from Penicillium sp. HZ-5

Zhang,

Li,

Zhang

et al. 2024

J. Agric. Food Chem.

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Nine new sesquiterpene alkaloids, eurochevalierines A−I (1−9), were separated from the rice cultures of the endophytic fungus Penicillium sp. HZ-5 originated from the fresh leaf of Hypericum wilsonii N. Robson. The structures' illumination was conducted by single-crystal X-ray diffraction, extensive spectroscopic analysis, alkaline hydrolysis reaction, and Snatzke's method. Importantly, the antitumor activities screen of these isolates indicated that 1 could suppress triple negative breast cancer (TNBC) cell proliferation and induce apoptosis, with an IC 50 value of 5.4 μM, which is comparable to the positive control docetaxel (DXT). Flow cytometry experiments mentioned that compound 1 significantly reduced mitochondrial membrane potential (MMP) of TNBC cells. In addition, 1 could activate caspase-3 and elevated the levels of reactive oxygen species (ROS) and expressions of suppressive cytokines and chemokines. Further Western blot analysis showed that 1 could selectively induce mitochondriadependent apoptosis in TNBC cells via the BAX/BCL-2 pathway. Remarkably, these finding provide a new natural product skeleton for the treatment of TNBC.

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Iridoid for drug discovery: Structural modifications and bioactivity studies

Wang,

Zheng,

Yang

et al. 2024

Med Chem Res

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Discovery of ergosterol derivative from Aspergillus sp. TJ507 that protects against hepatic ischemia/reperfusion injury

Cited by 4 publications

References 20 publications

Bioactive Indole Alkaloid from Aspergillus amoenus TJ507 That Ameliorates Hepatic Ischemia/Reperfusion Injury

Bioactive Indole Alkaloid from Aspergillus amoenus TJ507 That Ameliorates Hepatic Ischemia/Reperfusion Injury

Eurochevalierines A–I, Sesquiterpene Alkaloid Hybrids with Anti-Triple Negative Breast Cancer Activity from Penicillium sp. HZ-5

Iridoid for drug discovery: Structural modifications and bioactivity studies

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