Discovery of genes associated with cadmium accumulation from gill of scallop Chlamys farreri based on high-throughput sequencing

Zhang, Hui; Zhai, Yuanzheng; Ye, Lilin; Jiang, Yanhua; Li, Fengling

doi:10.1007/s13258-016-0391-9

Cited by 4 publications

(3 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Numerous environmental contaminants have been shown to induce epigenetic changes to a wide range of ecologically relevant organisms (Table ), such as mammals, , plants, − insects, , fish, − nematode worms, molluscs, and reptiles. , Several of these studies have cited contaminant-induced hypermethylation of specific genes, suggesting that epigenetic alterations vary with contaminant type. For example, studies have demonstrated that regions of the rat ( Rattus norvegicus ) genome are differentially methylated in response to exposure from different contaminants including dioxins, plastics, and pesticides .…”

Section: Contaminant-induced Epigenetic Changesmentioning

confidence: 99%

“…Numerous environmental contaminants have been shown to induce epigenetic changes to a wide range of ecologically relevant organisms (Table 1), such as mammals, 22,25 plants, 26−28 insects, 29,30 fish, 31−33 nematode worms, 34 molluscs, 35 and reptiles. 36,37 Several of these studies have cited contaminant-induced hypermethylation of specific genes, suggesting that epigenetic alterations vary with contaminant type.…”

Section: Contaminant-induced Epigenetic Changesmentioning

confidence: 99%

See 1 more Smart Citation

Incorporating Transgenerational Epigenetic Inheritance into Ecological Risk Assessment Frameworks

Shaw

Judy

Kumar

et al. 2017

Environ. Sci. Technol.

View full text Add to dashboard Cite

Chronic exposure to environmental contaminants can induce heritable "transgenerational" modifications to organisms, potentially affecting future ecosystem health and functionality. Incorporating transgenerational epigenetic heritability into risk assessment procedures has been previously suggested. However, a critical review of existing literature yielded numerous studies claiming transgenerational impacts, with little compelling evidence. Therefore, contaminant-induced epigenetic inheritance may be less common than is reported in the literature. We identified a need for multigeneration epigenetic studies that extend beyond what could be deemed "direct exposure" to F1 and F2 gametes and also include subsequent multiple nonexposed generations to adequately evaluate transgenerational recovery times. Also, increased experimental replication is required to account for the highly variable nature of epigenetic responses and apparent irreproducibility of current studies. Further, epigenetic end points need to be correlated with observable detrimental organism changes before a need for risk management can be properly determined. We suggest that epigenetic-based contaminant studies include concentrations lower than current "EC" or "Lowest Observable Effect Concentrations" for the organism's most sensitive phenotypic end point, as higher concentrations are likely already regulated. Finally, we propose a regulatory framework and optimal experimental design that enables transgenerational epigenetic effects to be assessed and incorporated into conventional ecotoxicological testing.

show abstract

Section: Contaminant-induced Epigenetic Changesmentioning

confidence: 99%

Section: Contaminant-induced Epigenetic Changesmentioning

confidence: 99%

Incorporating Transgenerational Epigenetic Inheritance into Ecological Risk Assessment Frameworks

Shaw

Judy

Kumar

et al. 2017

Environ. Sci. Technol.

View full text Add to dashboard Cite

show abstract

“…Cd dispersion was recently observed in coastal areas and is thought to be very dangerous to the health of aquatic organisms, such as shells, fishes, crabs, and scallops. Cd pollution has become a serious problem associated with aquatic products …”

Section: Introductionmentioning

confidence: 99%

Integrated transcriptomic and proteomic analyses of the tissues from the digestive gland of Chlamys farreri following cadmium exposure

Zhang

Zhai

2019

J of Cellular Biochemistry

Self Cite

View full text Add to dashboard Cite

Objectives Cadmium causes the pollution of marine habitat and Chlamys farreri is an effective concentrator of heavy metals, the aim of this study was to study the response mechanism of C. farreri to cadmium stress at transcriptomic and proteomic levels. Methods Transcriptomic analysis based on RNA‐sequencing and proteomic analysis based on isobaric tags for relative and absolute quantitation were performed to reveal the molecular response of C. farreri to different concentrations of cadmium (0.1, 0.3, and 1 mg/L). In addition, a protein‐protein interaction (PPI) network was constructed based on the Cytoscape tool to identify hub proteins related to the response of C. farreri to cadmium stress. Results A total of 24 190 unigenes from 58 683 candidates were annotated in known databases. The numbers of the differentially expressed unigenes (DEGs) was different among the three cadmium‐treated groups compared with the control group. DEGs were involved in many pathways such as ABC transporters, protein processing in endoplasmic reticulum and endocytosis. A total of 660 proteins were identified, and differentially expressed proteins (DEPs) among different groups were determined. The overlapping DEGs and DEPs were associated with cadmium response. The upregulated unigene0002618 and downregulated unigene0000904 may be more important for the response of C. farreri to cadmium stress. Unigene0009750 was the hub protein in the PPI network with the highest degree of 20. Conclusions Our transcriptomic and proteomic analyses elucidated the molecular response of C. farreri to cadmium stress.

show abstract

Hyperaccumulation of cadmium by scallop Chlamys farreri revealed by comparative transcriptome analysis

et al. 2020

View full text Add to dashboard Cite

Discovery of genes associated with cadmium accumulation from gill of scallop Chlamys farreri based on high-throughput sequencing

Cited by 4 publications

References 28 publications

Incorporating Transgenerational Epigenetic Inheritance into Ecological Risk Assessment Frameworks

Incorporating Transgenerational Epigenetic Inheritance into Ecological Risk Assessment Frameworks

Integrated transcriptomic and proteomic analyses of the tissues from the digestive gland of Chlamys farreri following cadmium exposure

Hyperaccumulation of cadmium by scallop Chlamys farreri revealed by comparative transcriptome analysis

Contact Info

Product

Resources

About