Discovery of potent and selective inhibitors of calmodulin-dependent kinase II (CaMKII)

Koltun, Dmitry O.; Parkhill, Eric Q.; Kalla, Rao; Perry, Thao; Elzein, Elfatih; Li, Xiaofen; Simonovich, Scott P.; Ziebenhaus, Christopher; Hansen, Timothy R.; Marchand, Bruno; Hung, WaiLok K.; Lagpacan, Leanna; Hung, Magdeleine; Aoyama, Ron; Murray, Bernard P.; Perry, Jason K.; Somoza, John R.; Villaseñor, Armando G.; Pagratis, Nikos; Zablocki, Jeff

doi:10.1016/j.bmcl.2017.10.040

Cited by 10 publications

(3 citation statements)

References 11 publications

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“…The imidazopyridine scaffold has been reported in the structures of various kinase inhibitors, such as KDR kinase, calmodulin-dependent kinase II (CaMKII), Glycogen Synthase Kinase-3, cyclin-dependent kinase (CDK), Bruton's tyrosine kinase, AKT Kinase, c-Met kinase, VEGFR2 kinase, FLT3 kinase, Pan-JAK, Aurora-A kinase, phosphatidylinositol-3-kinase (PI3K) and apoptosis signal-regulating kinase 1 (ASK1) [182][183][184][185][186][187][188][189][190][191][192][193][194][195].…”

Section: Imidazopyridinesmentioning

confidence: 99%

Fused Pyridine Derivatives: Synthesis and Biological Activities

Istanbullu¹,

Bayraktar²,

Saylam³

2023

Exploring Chemistry With Pyridine Derivatives

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Five-membered heteroaromatic ring fused pyridine derivatives are of increasing interest in drug design and medicinal chemistry. The structural similarity of many drugs (especially antiviral and anticancer ones) with DNA bases such as adenine and guanine is a key factor to explain their effectiveness. Apart from these, it is also found in the structures of substances with antituberculosis, antibacterial, antifungal, anti-inflammatory, and antimalarial activities. Another advantage of this group of compounds is their positive contribution to solubility, polarity, lipophilicity, and hydrogen bonding capacity properties of the compounds they are incorporated into. In this chapter, various bioactivities of fused pyridine derivatives will be categorized and summarized.

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Section: Imidazopyridinesmentioning

confidence: 99%

Fused Pyridine Derivatives: Synthesis and Biological Activities

Istanbullu¹,

Bayraktar²,

Saylam³

2023

Exploring Chemistry With Pyridine Derivatives

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Section: Imidazopyridinesmentioning

confidence: 99%

Exploring Chemistry with Pyridine Derivatives

2023

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“…Under these conditions, the required intermediate 105 was isolated in 50 % yield (Scheme 67). Bendjeddou et al [138] reported the synthesis of various Recently, Koltun et al [139] Intermediate 163 was then coupled with appropriate boronic acid to yield compound 164 (Scheme 75).…”

Section: Sequential Couplingsmentioning

confidence: 99%

Synthesis and Functionalization of Imidazo[1,2‐b]Pyridazine by Means of Metal‐Catalyzed Cross‐Coupling Reactions

et al. 2021

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This review surveys the recent developments in organometallic-chemistry-based methods for the preparation of imidazo [1,2-b]pyridazines by cyclization as well as their functionalization by means of cross-coupling reactions such as Sonogashira, Heck, Negishi, Suzuki-Miyaura, Kumada and Stille. In addition, the advances made on the CÀ H activation of imidazo[1,2-b] pyridazines using C-arylation, C-benzylation and C-alkylation are also reviewed. Furthermore, the recent reports on the Narylation of this heterocyclic system are discussed and highlighted. The sequential couplings as well as the one-pot functionalization of two different positions on the imidazo[1,2b]pyridazine systems are also reviewed. Procedures in which metal-based catalysis is not involved in the functionalization of imidazo [1,2-b]pyridazines are not included in this review.(MTCC 3382), Staphylococcus aureus (MTCC 3160), Bacillus subtilis (MTCC 297), and Gram-negative bacteria: Pseudomonas aeruginosa (MTCC 1034), Klebsiella pneumoniae (MTCC).

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Discovery of potent and selective inhibitors of calmodulin-dependent kinase II (CaMKII)

Cited by 10 publications

References 11 publications

Fused Pyridine Derivatives: Synthesis and Biological Activities

Fused Pyridine Derivatives: Synthesis and Biological Activities

Exploring Chemistry with Pyridine Derivatives

Synthesis and Functionalization of Imidazo[1,2‐b]Pyridazine by Means of Metal‐Catalyzed Cross‐Coupling Reactions

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