Discovery of pyridine-2-ones as novel class of multidrug resistance (MDR) modulators: First structure–activity relationships

Photocatalyst-Free Singlet Oxygen-Induced Oxygenation: A Strategy for the Preparation of 5-Cyano-2-pyridones Driven by Blue-Light Irradiation

“…For example, the naturally occurring ricinine has an anticonvulsant activity and can be used as a cognition-enhancing drug . Many synthetic 2-pyridones, including a 2-pyridone derivative, used as a multidrug resistance (MDR) modulator, and milrinone, used as a phosphodiesterase III inhibitor, as shown in Scheme a. The above-mentioned structures all contain a 2-pyridone parent nucleus and cyano group, which has stimulated our interest in the study of cyano-substituted 2-pyridone compounds.…”

Convenient Synthesis and Antibacterial Activity of Tricyclic Azine Derivatives

“…The well known diverse biological activities of compounds containing pyridines and pyrimidines as components of fused azines [8][9][10][11][12][13][14][15][16]21,[22][23][24][25][26][27][28] prompted us to test and study the antibacterial activities of some of the newly synthesised products. Table 1 shows that most of the tested compounds had moderate to high activity against all four microorganisms.…”

Discovery of substituted 1,4-dihydroquinolines as novel promising class of P-glycoprotein inhibitors: First structure–activity relationships and bioanalytical studies

“…13 We reported some P-gp inhibiting effects for quinolone-related pyridine-2-ones. 14 The structures of both the quinolones and the pyridine-2-ones are shown in Figure 1.…”