Discriminant function for prognostic indexes and probability of death in chronic severe hepatitis B

Ke, Wei-Min; Ye, Yi-Nong; Huang, Shi

doi:10.1007/s00535-003-1162-3

Cited by 30 publications

(22 citation statements)

References 29 publications

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“…The diagnoses were complied with the diagnostic criteria of the 2000 Xi'an Viral Hepatitis Management Scheme issued by the Chinese Society of Infectious Diseases and Parasitology, and the Chinese Society of Hepatology, of the Chinese Medical Association (36). The standards for diagnoses of AHB, CHB, and CSHB have been described in detail previously (37,38). Briefly, AHB patients are defined as those who displayed hepatitis B surface Ag (HBsAg)-negative conversion within 6 mo after the initial onset of symptoms due to HBV infection.…”

Section: Subjectsmentioning

confidence: 99%

Circulating and Liver Resident CD4+CD25+ Regulatory T Cells Actively Influence the Antiviral Immune Response and Disease Progression in Patients with Hepatitis B

Jin

et al. 2006

The Journal of Immunology

407

363

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CD4+CD25+ regulatory T cells (Treg) have been shown to maintain immune tolerance against self and foreign Ags, but their role in persistent viral infection has not been well-defined. In this study, we investigated whether and where CD4+CD25+ Treg contribute to the development of chronic hepatitis B (CHB). One hundred twenty-one patients were enrolled, including 16 patients with acute hepatitis B, 76 with CHB, and 29 with chronic severe hepatitis B. We demonstrated that in chronic severe hepatitis B patients, the frequencies of CD4+CD25+ Treg in both PBMC and liver-infiltrating lymphocytes were significantly increased and there was a dramatic increase of FoxP3+-cell and inflammatory cell infiltration in the liver compared with healthy controls. In CHB patients, circulating CD4+CD25+ Treg frequency significantly correlates with serum viral load. In acute hepatitis B patients, circulating CD4+CD25+ Treg frequency was initially low and with time, the profile reversed to exhibit an increased number of circulating Treg in the convalescent phase and restored to normal levels upon resolution. In PBMC taken from infected patients, depletion of CD4+CD25+ Treg led to an increase of IFN-γ production by HBV-Ag-stimulated PBMC. In addition, CD4+CD25+ Treg were capable of suppressing proliferation of autologous PBMC mediated by HBV Ags, which probably reflects the generation of HBV-Ag-specific Treg in circulation and in the liver of HBV-infected patients. Together, our findings suggest that CD4+CD25+ Treg play an active role not only in modulating effectors of immune response to HBV infection, but also in influencing the disease prognosis in patients with hepatitis B.

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Section: Subjectsmentioning

confidence: 99%

Circulating and Liver Resident CD4+CD25+ Regulatory T Cells Actively Influence the Antiviral Immune Response and Disease Progression in Patients with Hepatitis B

Jin

et al. 2006

The Journal of Immunology

407

363

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“…2000; Ke et al 2003;Wasmuth et al 2005;Shiv et al 2009). All patients were seronegative for markers of hepatitis A, C, D and E viruses and HIV, no evidence for hepatocelluar carcinoma or other metastatic liver tumor, no evidence of autoimmune liver disease; and no immunosuppressive medication within the 3 months before study entry.…”

Section: Patientsmentioning

confidence: 99%

“…In some eastern countries, such as in China, HBV infection accounts for nearly 80% of all the ACLF cases (Zou et al 2002;Ke et al 2003;Custer et al 2004). Wasmuth et al (2005) reported that there was reduced cellular immune response in the ACLF patients.…”

mentioning

confidence: 99%

Enhanced Demethylation of Interferon-.GAMMA. Gene Promoter in Peripheral Blood Mononuclear Cells Is Associated with Acute-on-Chronic Hepatitis B Liver Failure

Fan

Zou

Long

et al. 2011

Tohoku J. Exp. Med.

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Acute-on-chronic hepatitis B liver failure (ACHBLF) refers to liver failure occurring in patients with chronic hepatitis B (CHB) related liver diseases. Interferon-γ (IFN-γ) plays an important role in the exacerbation of liver function. However, the exact mechanism, by which IFN-γ mediates ACHBLF, is not fully understood. Forty patients with ACHBLF, fifteen patients with CHB and ten healthy controls were included in this present study. ELISA was performed to measure the level of serum IFN-γ. The methylation status of IFN-γ promoter in peripheral blood mononuclear cells (PBMCs) was determined using methylation-specific PCR. Model for End-stage Liver Disease (MELD) scoring was performed for evaluating the severity of liver failure. The serum level of IFN-γ in patients with ACHBLF or CHB was significantly lower than that in healthy controls, while the serum IFN-γ level in ACHBLF patients was significantly higher than that in CHB patients. In ACHBLF patients, the level of IFN-γ was positively correlated with total bilirubin and MELD score, but negatively correlated with prothrombin time activity. These results suggest the involvement of IFN-γ in the pathogenesis of ACHBLF. Importantly, the degree of methylation of the IFN-γ gene promoter in ACHBLF patients (60%, 24/40) was significantly lower than that in CHB patients (93%, 14/15), but was higher than that in the control group (20%, 2/10). Furthermore, in ACHBLF patients, the serum IFN-γ level was significantly higher in unmethylation group than that in methylation group. In conclusion, enhanced demethylation of IFN-γ gene promoter in PBMCs may be associated with the onset of ACHBLF.

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“…Decompensable cirrhosis belonged to ChildPugh B, C, the diagnostic criteria included serious hepatic function abnormalities, such as A < 35 g/L, A/G < 1.0, Bil > 35 μmol/L, PTA < 60%, and ascites, hepatic encephalopathy, upper gastrointestinal varices or bleeding. Diagnostic criteria of chronic severe hepatitis B [18] included the basic conditions, i.e. the course of hepatitis B surface antigen-positive exceeded six months and the level of serum bilirubin in liver failure index exceeded ten times compared by normal level (17.1 μmol/L), which was above 171 μmol/L.…”

Section: Subjects and Diagnostic Criteriamentioning

confidence: 99%

Portalsystemic hemodynamic changes in chronic severe hepatitis B: An ultrasonographic study

Song²,

Ke³

et al. 2008

WJG

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Discriminant function for prognostic indexes and probability of death in chronic severe hepatitis B

Abstract: The discriminant function is an objective, convenient, and practical method to assess the prognosis of chronic severe hepatitis B.

Cited by 30 publications

References 29 publications

Circulating and Liver Resident CD4+CD25+ Regulatory T Cells Actively Influence the Antiviral Immune Response and Disease Progression in Patients with Hepatitis B

Circulating and Liver Resident CD4+CD25+ Regulatory T Cells Actively Influence the Antiviral Immune Response and Disease Progression in Patients with Hepatitis B

Enhanced Demethylation of Interferon-.GAMMA. Gene Promoter in Peripheral Blood Mononuclear Cells Is Associated with Acute-on-Chronic Hepatitis B Liver Failure

Portalsystemic hemodynamic changes in chronic severe hepatitis B: An ultrasonographic study

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