Discrimination of different geographic varieties of Gymnema sylvestre , an anti-sweet plant used for the treatment of type 2 diabetes

Pham, Ha Thanh Tung; Hoang, Minh Hien; Ha, Thi Kim Quy; Dang, Lan Huong; Tran, Van On; Nguyen, Thi Bich Thu; Lee, Chul‐Ho; Oh, Won Keun

doi:10.1016/j.phytochem.2018.02.013

Cited by 20 publications

(24 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Triterpene glycosides isolated from rare medicinal plants often display a wide range of pharmacological activities, such as anti-inflammatory [21], antifungal [22], antimicrobial [23], anti-cancer [24], anti-diabetic [25] and immunomodulatory [26] effects. Indeed, triterpene saponins are the key active constituents of major medicinal herbs such as Panax ginseng (Araliaceae), Gynostemma pentaphyllum (Cucurbitaceae) and Glycyrrhiza uralensis (Fabaceae) [27,28].…”

Section: Discussionmentioning

confidence: 99%

Enhancement of an In Vivo Anti-Inflammatory Activity of Oleanolic Acid through Glycosylation Occurring Naturally in Stauntonia hexaphylla

et al. 2020

View full text Add to dashboard Cite

Stauntonia hexaphylla (Lardizabalaceae) has been used as a traditional herbal medicine in Korea and China for its anti-inflammatory and analgesic properties. As part of a bioprospecting program aimed at the discovery of new bioactive compounds from Korean medicinal plants, a phytochemical study of S. hexaphylla leaves was carried out leading to isolation of two oleanane-type triterpene saponins, 3-O-[β-d-glucopyranosyl (1→2)-α-l-arabinopyranosyl] oleanolic acid-28-O-[β-d-glucopyranosyl (1→6)-β-d-glucopyranosyl] ester (1) and 3-O-α-l-arabinopyranosyl oleanolic acid-28-O-[β-d-glucopyranosyl (1→6)-β-d-glucopyranosyl] ester (2). Their structures were established unambiguously by spectroscopic methods such as one- and two-dimensional nuclear magnetic resonance and infrared spectroscopies, high-resolution electrospray ionization mass spectrometry and chemical reactions. Their anti-inflammatory activities were examined for the first time with an animal model for the macrophage-mediated inflammatory response as well as a cell-based assay using an established macrophage cell line (RAW 264.7) in vitro. Together, it was concluded that the saponin constituents, when they were orally administered, exerted much more potent activities in vivo than their sapogenin core even though both the saponins and the sapogenin molecule inhibited the RAW 264.7 cell activation comparably well in vitro. These results imply that saponins from S. hexaphylla leaves have a definite advantage in the development of oral medications for the control of inflammatory responses.

show abstract

Section: Discussionmentioning

confidence: 99%

Enhancement of an In Vivo Anti-Inflammatory Activity of Oleanolic Acid through Glycosylation Occurring Naturally in Stauntonia hexaphylla

et al. 2020

View full text Add to dashboard Cite

show abstract

“…55P0110 is one of these synthetic compounds that has been tested for potential antidiabetic activity [70]. Despite no evidence of a direct molecular target, it is believed that this compound enhances glucose-stimulated insulin release [69].…”

Section: P0110mentioning

confidence: 99%

“…Gymnema sylvestre is a tropical plant native to the Indian forests and also a well-known Ayurvedic anti-sweet plant used in T2DM treatment [70]. It is an important fact that Gymnema sylvestre varies in its chemical composition depending on the geography: species from Vietnam are not equal to those in India.…”

Section: Gymnema Sylvestre (Gurmar)mentioning

confidence: 99%

“…It is an important fact that Gymnema sylvestre varies in its chemical composition depending on the geography: species from Vietnam are not equal to those in India. In 3T3-L1 adipocyte cells, gymnemosides produce a stimulating effect on 2-NBDG uptake, thus being promising as lead molecules for novel anti-diabetic therapies [70].…”

Section: Gymnema Sylvestre (Gurmar)mentioning

confidence: 99%

See 1 more Smart Citation

Sugar-Lowering Drugs for Type 2 Diabetes Mellitus and Metabolic Syndrome—Review of Classical and New Compounds: Part-I

et al. 2019

View full text Add to dashboard Cite

Diabetes mellitus (DM) is a metabolic disorder characterized by chronic hyperglycemia together with disturbances in the metabolism of carbohydrates, proteins and fat, which in general results from an insulin availability and need imbalance. In a great number of patients, marketed anti-glycemic agents have shown poor effectiveness in maintaining a long-term glycemic control, thus being associated with severe adverse effects and leading to an emerging interest in natural compounds (e.g., essential oils and other secondary plant metabolites, namely, flavonoid-rich compounds) as a novel approach for prevention, management and/or treatment of either non-insulin-dependent diabetes mellitus (T2DM, type 2 DM) and/or Metabolic Syndrome (MS). In this review, some of these promising glucose-lowering agents will be comprehensively discussed.

show abstract

“…[1][2][3][4] The principle chemical component of G. sylvestre are pregnaneglycosides [5][6][7] and oleanane saponins. [8][9][10][11][12][13][14][15][16] In the previous paper, we reported the isolation and structure elucidation of twelve pregnaneglycosides name gymsylosides A-F and gymnepregosides R-T. 6,7 Continue researching on bioactive compounds from the leave of G. sylvestre, we reported herein the isolation and structural elucidation of two new pregnaneglycosides and their αglucosidase and αamylase inhibition activities.…”

mentioning

confidence: 99%

Gymsyloside F and Gymsyloside G, Two New Pregnane Glycosides From the Leaves of Gymnema sylvestre and Their α-Glucosidase and α-Amylase Inhibitory Activities

Yến

Thanh

et al. 2021

Natural Product Communications

View full text Add to dashboard Cite

Two new pregnane glycosides were isolated from the leaves of Gymnema sylvestre (Retz.) R.Br. ex Sm. Their chemical structures were determined as (20 S)−12 β-tigloyloxy-5 α-hydroperoxy-3 β,8 β,14 β,17 β,20-pentahydroxypregn-6-ene 3- O-β-D-glucopyranosyl-(1→4)‐6-deoxy-3- O-methyl- β-D-allopyranosyl-(1→4)- β-D-oleandropyranosyl-(1→4)- β-D-cymaropyranosyl-(1→4)- β-D-cymaropyranoside (1) and (20 S)−12 β-benzoyloxy-5 α-hydroperoxy-3 β,8 β,14 β,17 β,20-pentahydroxypregn-6-ene 3- O-β-D-glucopyranosyl-(1→4)‐6-deoxy-3- O-methyl- β-D-allopyranosyl-(1→4)- β-D-oleandropyranosyl-(1→4)- β-D-cymaropyranosyl-(1→4)- β-D-cymaropyranoside (2) on the basis of the extensive spectroscopic methods, including 1D, 2D NMR, HRESIMS, and in comparison with the reported data. At the concentration of 200 µM, compounds 1 and 2 showed moderate anti α-glucosidase and α-amylase activities with inhibitory percentage of 31.1 ± 1.2 and 42.3 ± 1.7% (for α-glucosidase), and 27.8 ± 1.3 and 34.5 ± 1.5% (for α-amylase), respectively.

show abstract

Discrimination of different geographic varieties of Gymnema sylvestre , an anti-sweet plant used for the treatment of type 2 diabetes

Cited by 20 publications

References 23 publications

Enhancement of an In Vivo Anti-Inflammatory Activity of Oleanolic Acid through Glycosylation Occurring Naturally in Stauntonia hexaphylla

Enhancement of an In Vivo Anti-Inflammatory Activity of Oleanolic Acid through Glycosylation Occurring Naturally in Stauntonia hexaphylla

Sugar-Lowering Drugs for Type 2 Diabetes Mellitus and Metabolic Syndrome—Review of Classical and New Compounds: Part-I

Gymsyloside F and Gymsyloside G, Two New Pregnane Glycosides From the Leaves of Gymnema sylvestre and Their α-Glucosidase and α-Amylase Inhibitory Activities

Contact Info

Product

Resources

About