Discrimination of skin diseases using the multimodal imaging approach

Vogler, Nadine; Heuke, Sandro; Akimov, Dmitry; Latka, Ines; Kluschke, Franziska; Röwert‐Huber, Hans‐Joachim; Lademann, Jürgen; Dietzek, Benjamin; Popp, Jürgen

doi:10.1117/12.921748

Cited by 3 publications

(2 citation statements)

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“…87 This has the potential to be the first case where it is possible to distinguish cancer cells based on spectroscopy alone, rather than having to interpret the morphological data. Fu et al .…”

Section: Applications Of Multiphoton Microscopy In Different Areasmentioning

confidence: 99%

“…One new trend in melanoma imaging stresses the importance of quantifying the proportion of pheomelanin and eumelanin, since it has been argued that higher proportions of pheomelanin in skin are positively correlated with skin cancer. 87 This has the potential to be the first case where it is possible to distinguish cancer cells based on spectroscopy alone, rather than having to interpret the morphological data. Fu et al .…”

Section: Applications Of Multiphoton Microscopy In Different Areasmentioning

confidence: 99%

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Application of multiphoton microscopy in dermatological studies: A mini-review

Yew

Rowlands

2014

J. Innov. Opt. Health Sci.

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This review summarizes the historical and more recent developments of multiphoton microscopy, as applied to dermatology. Multiphoton microscopy offers several advantages over competing microscopy techniques: there is an inherent axial sectioning, penetration depths that compete well with confocal microscopy on account of the use of near-infrared light, and many two-photon contrast mechanisms, such as second-harmonic generation, have no analogue in one-photon microscopy. While the penetration depths of photons into tissue are typically limited on the order of hundreds of microns, this is of less concern in dermatology, as the skin is thin and readily accessible. As a result, multiphoton microscopy in dermatology has generated a great deal of interest, much of which is summarized here. The review covers the interaction of light and tissue, as well as the various considerations that must be made when designing an instrument. The state of multiphoton microscopy in imaging skin cancer and various other diseases is also discussed, along with the investigation of aging and regeneration phenomena, and finally, the use of multiphoton microscopy to analyze the transdermal transport of drugs, cosmetics and other agents is summarized. The review concludes with a look at potential future research directions, especially those that are necessary to push these techniques into widespread clinical acceptance.

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Section: Applications Of Multiphoton Microscopy In Different Areasmentioning

confidence: 99%

Section: Applications Of Multiphoton Microscopy In Different Areasmentioning

confidence: 99%

Application of multiphoton microscopy in dermatological studies: A mini-review

Yew

Rowlands

2014

J. Innov. Opt. Health Sci.

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Ex vivo optical measurements of glucose diffusion kinetics in native and diabetic mouse skin

Tuchina

Shi

Bashkatov

et al. 2015

Journal of Biophotonics

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The aim of this study was to estimate the glucose diffusion coefficients ex vivo in skin of mice with diabetes induced in vivo by alloxan in comparison to non‐diabetic mice. The temporal dependences of collimated transmittance of tissue samples immersed in glucose solutions were measured in the VIS‐NIR spectral range to quantify the glucose diffusion/permeability coefficients and optical clearing efficiency of mouse skin. The average thickness of intact healthy and diabetic skin was 0.023 ± 0.006 cm and 0.019 ± 0.005 cm, respectively. Considerable differences in optical and kinetic properties of diabetic and non‐diabetic skin were found: clearing efficiency was 1.5‐fold better and glucose diffusivity was 2‐fold slower for diabetic skin. Experimental Setup for measuring collimated transmittance spectra of mouse skin samples.magnified imageExperimental Setup for measuring collimated transmittance spectra of mouse skin samples.

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Applications of Multiphoton Microscopy in Dermatology

Yew

Rowlands

2016

Imaging in Dermatology

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Discrimination of skin diseases using the multimodal imaging approach

Cited by 3 publications

References 0 publications

Application of multiphoton microscopy in dermatological studies: A mini-review

Application of multiphoton microscopy in dermatological studies: A mini-review

Ex vivo optical measurements of glucose diffusion kinetics in native and diabetic mouse skin

Applications of Multiphoton Microscopy in Dermatology

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