Discriminative Auditory Fear Learning Requires Both Tuned and Nontuned Auditory Pathways to the Amygdala

Antunes, Raquel A. G.; Moita, Marta A.

doi:10.1523/jneurosci.1037-10.2010

Cited by 65 publications

(60 citation statements)

References 33 publications

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“…One possibility is that the association between cortical and thalamic projection is necessary for a discriminative form of fear learning. Although the activation of either the cortical or thalamic input is sufficient for fear-conditioning learning (Campeau and Davis, 1995;Kwon and Choi, 2009), in auditory discriminative fear learning, coactivation of both inputs might be necessary for discrimination (Antunes and Moita, 2010). This observation is consistent with a cooperative interaction between the cortical and thalamic inputs.…”

Section: Discussionsupporting

confidence: 67%

Asymmetrical Synaptic Cooperation between Cortical and Thalamic Inputs to the Amygdale

Fonseca

2013

Neuropsychopharmacol

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Fear conditioning, a form of associative learning is thought to involve the induction of an associative long-term potentiation of cortical and thalamic inputs to the lateral amygdala. Here, we show that stimulation of the thalamic input can reinforce a transient form of plasticity (E-LTP) induced by weak stimulation of the cortical inputs. This synaptic cooperation occurs within a time window of 30 min, suggesting that synaptic integration at amygdala synapses can occur within large time windows. Interestingly, we found that synaptic cooperation is not symmetrical. Reinforcement of a thalamic E-LTP by subsequent cortical stimulation is only observed within a shorter time window. We found that activation of endocannabinoid CB1 receptors is involved in the time restriction of thalamic and cortical synaptic cooperation in an activity-dependent manner. Our results support the hypothesis that synaptic cooperation can underlie associative learning and that synaptic tagging and capture is a general mechanism in synaptic plasticity.

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Section: Discussionsupporting

confidence: 67%

Asymmetrical Synaptic Cooperation between Cortical and Thalamic Inputs to the Amygdale

Fonseca

2013

Neuropsychopharmacol

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“…Together, our data revealed that auditory fearful memories are specifically consolidated at the auditory cortex level, whereas thalamic nuclei are not necessary for this process. Therefore, MG may be involved in the acquisition and retrieval processes, as reported previously (Campeau and Davis, 1995;Antunes and Moita, 2010;Weinberger, 2011), whereas it is dispensable for the consolidation of long-term memories.…”

Section: Auditory Cortex Is Necessary For Early Consolidation Of Recesupporting

confidence: 62%

“…According to previous studies (Poremba et al, 1997(Poremba et al, , 1998Bao et al, 2001;Sacco and Sacchetti, 2010;Cambiaghi et al, 2015;Grosso et al, 2015b), Te2 is essential for the encoding of the association between a tone and its emotional/motivational learned charge, not merely for the processing or encoding of the physical attribute of the CS. The fact that only the combined, not the individual, blockade of Te2 and Te1 impaired recent memory consolidation suggests that Te1 participates in memory information.…”

Section: Discriminative Fear Memory Processes In the Absence Of The Amentioning

confidence: 99%

Differential Recruitment of Auditory Cortices in the Consolidation of Recent Auditory Fearful Memories

Cambiaghi¹,

Grosso²,

Renna³

et al. 2016

J. Neurosci.

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Memories of frightening events require a protracted consolidation process. Sensory cortex, such as the auditory cortex, is involved in the formation of fearful memories with a more complex sensory stimulus pattern. It remains controversial, however, whether the auditory cortex is also required for fearful memories related to simple sensory stimuli. In the present study, we found that, 1 d after training, the temporary inactivation of either the most anterior region of the auditory cortex, including the primary (Te1) cortex, or the most posterior region, which included the secondary (Te2) component, did not affect the retention of recent memories, which is consistent with the current literature. However, at this time point, the inactivation of the entire auditory cortices completely prevented the formation of new memories. Amnesia was site specific and was not due to auditory stimuli perception or processing and strictly related to the interference with memory consolidation processes. Strikingly, at a late time interval 4 d after training, blocking the posterior part (encompassing the Te2) alone impaired memory retention, whereas the inactivation of the anterior part (encompassing the Te1) left memory unaffected. Together, these data show that the auditory cortex is necessary for the consolidation of auditory fearful memories related to simple tones in rats. Moreover, these results suggest that, at early time intervals, memory information is processed in a distributed network composed of both the anterior and the posterior auditory cortical regions, whereas, at late time intervals, memory processing is concentrated in the most posterior part containing the Te2 region.

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“…As ACx and MGN inputs can convey distinct information to the LA and play different roles in discriminative fear conditioning (Antunes and Moita, 2010), we examined these pathways separately and found that the AMPA/NMDA ratio was significantly higher in the FC group than in the NS group in the ACx-LA pathway (p < 0.05, unpaired t test; Figures S5D-S5F), but not in the MGN-LA pathway (p = 0.63, unpaired t test; Figures S5G and S5H), indicating postsynaptically expressed LTP was selectively induced in the ACx-LA pathway in discriminative fear learning. In the ACx/MGN inputs to the amygdalo-striatal transition area (ASt), we did not detect significant difference in the AMPA/NMDA ratio between groups (p = 0.35, unpaired t test; Figures S5I-S5K), suggesting that LTP associated with discriminative fear learning is pathway specific.…”

Section: La Neuronal Ensemble Defined By Presynapticmentioning

confidence: 99%

Encoding of Discriminative Fear Memory by Input-Specific LTP in the Amygdala

Kim

Cho

2017

Neuron

145

126

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SUMMARYIn auditory fear conditioning, experimental subjects learn to associate an auditory conditioned stimulus (CS) with an aversive unconditioned stimulus. With sufficient training, animals fear conditioned to an auditory CS show fear response to the CS, but not to irrelevant auditory stimuli. Although long-term potentiation (LTP) in the lateral amygdala (LA) plays an essential role in auditory fear conditioning, it is unknown whether LTP is induced selectively in the neural pathways conveying specific CS information to the LA in discriminative fear learning. Here, we show that postsynaptically expressed LTP is induced selectively in the CS-specific auditory pathways to the LA in a mouse model of auditory discriminative fear conditioning. Moreover, optogenetically induced depotentiation of the CS-specific auditory pathways to the LA suppressed conditioned fear responses to the CS. Our results suggest that input-specific LTP in the LA contributes to fear memory specificity, enabling adaptive fear responses only to the relevant sensory cue.

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Discriminative Auditory Fear Learning Requires Both Tuned and Nontuned Auditory Pathways to the Amygdala

Cited by 65 publications

References 33 publications

Asymmetrical Synaptic Cooperation between Cortical and Thalamic Inputs to the Amygdale

Asymmetrical Synaptic Cooperation between Cortical and Thalamic Inputs to the Amygdale

Differential Recruitment of Auditory Cortices in the Consolidation of Recent Auditory Fearful Memories

Encoding of Discriminative Fear Memory by Input-Specific LTP in the Amygdala

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