Discriminative Preparation of Stable H- or J-Aggregates of Astaxanthin in Waterborne Chitosan/DNA Nanoparticles

Zhao, Yingyuan; Li, Jing; Dai, Mingqin; Dong, Ping; Liang, Xingguo; Komiyama, Makoto

doi:10.1246/cl.180940

Cited by 3 publications

(2 citation statements)

References 24 publications

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“…Although it is well accepted that the structure of AST determines its biological properties, few works could be found to reveal the relationship between AST aggregates and their physical and chemical properties due to the difficulties in obtaining stable AST aggregates [19,20]. Recently, we prepared two colloidal systems with differently aggregated AST to investigate the effect of dehydrated solvent on AST aggregation [21]. In this paper, AST H-aggregates and J-aggregates were precisely controlled and stably incorporated into DNA/chitosan nanoparticles by adjusting the feeding order of the polymers and ethanol content.…”

Section: Introductionmentioning

confidence: 99%

The Astaxanthin Aggregation Pattern Greatly Influences Its Antioxidant Activity: A Comparative Study in Caco-2 Cells

Dai

Yang

et al. 2020

Antioxidants

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Astaxanthin is an excellent antioxidant that can form unstable aggregates in biological or artificial systems. The changes of astaxanthin properties caused by molecular aggregation have gained much attention recently. Here, water-dispersible astaxanthin H- and J-aggregates were fabricated and stabilized by a natural DNA/chitosan nanocomplex (respectively noted as H-ADC and J-ADC), as evidenced by ultraviolet and visible spectrophotometry, Fourier transform infrared spectroscopy, and Raman spectroscopy. Compared with J-ADC, H-ADC with equivalent astaxanthin loading capacity and encapsulation efficiency showed smaller particle size and similar zeta potential. To explore the antioxidant differences between astaxanthin H- and J-aggregates, H-ADC and J-ADC were subjected to H2O2-pretreated Caco-2 cells. Compared with astaxanthin monomers and J-aggregates, H-aggregates showed a better cytoprotective effect by promoting scavenging of intracellular reactive oxygen species. Furthermore, in vitro 1,1-diphenyl-2-picrylhydrazyl and hydroxyl free radical scavenging studies confirmed a higher efficiency of H-aggregates than J-aggregates or astaxanthin monomers. These findings give inspiration to the precise design of carotenoid aggregates for efficient utilization.

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Section: Introductionmentioning

confidence: 99%

The Astaxanthin Aggregation Pattern Greatly Influences Its Antioxidant Activity: A Comparative Study in Caco-2 Cells

Dai

Yang

et al. 2020

Antioxidants

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“…However, the excited state dynamics of organic molecular systems containing two or more intramolecular hydrogen bonds is still in the initial stage. Via photoexcitation, the excited state intramolecular double proton transfer (ESDPT) behaviors are likely to occur along with dual intramolecular hydrogen bonding wires [17–20] . Particularly, the dual‐proton‐transfer tautomer formed by ESDPT reaction could tend to own longer wavelength fluorescence phenomena (even in the near infrared range).…”

Section: Introductionmentioning

confidence: 99%

Theoretical Insights into Excited‐State Stepwise Double Proton Transfer Associated with Solvent Polarity for 2‐bis(benzothia‐zolyl)naphthalene‐Diol Compound

Zhao

Yang

et al. 2023

ChemistrySelect

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Inspired by the excellent photochemical properties of 2‐(2′‐hydroxyphenyl)benzazole and its derivatives, in this work, the novel 2‐bis(benzothia‐zolyl)naphthalene‐diol (2‐BBTND) fluorophore is explored about its photo‐induced behaviors. The intramolecular double hydrogen bonding interaction and the excited state intramolecular double proton transfer (ESDPT) behavior of 2‐BBTND fluorophore are investigated in combination with different polar solvent environments. From the structural changes and charge recombination induced by photoexcitation, we can affirm that strong polar solvent environment promotes the excited state dynamical reaction for 2‐BBTND compound. By constructing potential energy surfaces (PESs) in S0 and S1 states, we clarify that 2‐BBTND fluorophore should undergo the stepwise ESDPT reaction after photoexcitation. Combined with the size of potential energy barriers along with reaction paths in different solvents, we finally propose a new solvent‐polarity‐dependent stepwise ESDPT for 2‐BBTND fluorophore.

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Fabrication and characterization of the H/J-type aggregates astaxanthin/bovine serum albumin/chitosan nanoparticles

Zhao

Liu

Zhang

et al. 2022

International Journal of Biological Macromolecules

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Discriminative Preparation of Stable H- or J-Aggregates of Astaxanthin in Waterborne Chitosan/DNA Nanoparticles

Cited by 3 publications

References 24 publications

The Astaxanthin Aggregation Pattern Greatly Influences Its Antioxidant Activity: A Comparative Study in Caco-2 Cells

The Astaxanthin Aggregation Pattern Greatly Influences Its Antioxidant Activity: A Comparative Study in Caco-2 Cells

Theoretical Insights into Excited‐State Stepwise Double Proton Transfer Associated with Solvent Polarity for 2‐bis(benzothia‐zolyl)naphthalene‐Diol Compound

Fabrication and characterization of the H/J-type aggregates astaxanthin/bovine serum albumin/chitosan nanoparticles

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