2009
DOI: 10.1124/jpet.108.145458
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Discriminative Stimulus Effects of 1-(2,5-Dimethoxy-4-Methylphenyl)-2-Aminopropane in Rhesus Monkeys: Antagonism and Apparent p A2 Analyses

Abstract: Discriminative stimulus effects of the serotonin (5-HT) receptor agonist 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM) have been studied in rats and, more recently, in rhesus monkeys. This study examined DOM, 2,5-dimethoxy-4-(n)-propylthiophenethylamine (2C-T-7), and dipropyltryptamine hydrochloride (DPT) alone and in combination with three antagonists, MDL100907 , to identify the 5-HT receptor subtype(s) that mediates the discriminative stimulus effects of these 5-HT receptor agonists. Four adult rhes… Show more

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Cited by 14 publications
(20 citation statements)
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“…Similarly, in the current study, drugs with agonist actions at 5-HT 1A receptors (F13714 and 8-OH-DPAT) fail to occasion responding on the DOM-associated lever in rats and monkeys. Together with published results, including data showing attenuation of the discriminative stimulus effects of DOM by 5-HT 2A receptor antagonists (e.g., Li et al, 2008bLi et al, , 2009a, the current results support the view that the DOM discriminative stimulus has similar pharmacological selectivity (5-HT 2A receptors) in rats and monkeys.…”
Section: Discussionsupporting
confidence: 74%
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“…Similarly, in the current study, drugs with agonist actions at 5-HT 1A receptors (F13714 and 8-OH-DPAT) fail to occasion responding on the DOM-associated lever in rats and monkeys. Together with published results, including data showing attenuation of the discriminative stimulus effects of DOM by 5-HT 2A receptor antagonists (e.g., Li et al, 2008bLi et al, , 2009a, the current results support the view that the DOM discriminative stimulus has similar pharmacological selectivity (5-HT 2A receptors) in rats and monkeys.…”
Section: Discussionsupporting
confidence: 74%
“…During experimental sessions, monkeys were seated in chairs (model R001; Primate Products, Miami, FL) that provided restraint at the neck and arms and were located in ventilated, sound-attenuating chambers equipped with two stimulus lights and two response levers. The monkeys responded under a schedule of stimulus-shock termination as described previously (Li et al, 2008b(Li et al, , 2009a. The feet of monkeys were placed in shoes mounted to the front of the chair and equipped with brass electrodes to which a brief (250-ms; 3-mA) electric shock could be delivered from an a.c. generator.…”
Section: Drug Discrimination In Rhesus Monkeysmentioning
confidence: 99%
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“…These results are consistent with a number of early experiments showing that classic psychedelics lack reinforcing properties, supporting the conclusion that these drugs do not lead to dependence or addiction. Li et al (2009) examined the discriminative stimulus effects of DOM, DPT, and 2,5-dimethoxy-4-n-propylthiophenethylamine (2C-T-7) in four adult rhesus monkeys. The nature of the cue was investigated using three antagonists: M100907, ketanserin, and ritanserin.…”
Section: F Monkey Modelsmentioning
confidence: 99%
“…Schild analysis was conducted as described previously (Li et al, 2009b) using the method of Arunlakshana and Schild (1959). The Schild plot was constructed by plotting the log of the dose ratio (agonist with antagonist divided by agonist alone) 2 1 as a function of the negative log dose of antagonist (moles per kilogram).…”
Section: Methodsmentioning
confidence: 99%