In this research work the outcomes of a hybrid experimental campaign are analyzed, in order to evaluate the influence of aftershock events on the frictional response of sliding-based isolation devices for buildings. To achieve this, a hybrid testing framework was accordingly defined, by considering a numerical substructure, in terms of a simplified analytical model of a case study structure, and a physical substructure, as a full-scale Curved Surface Slider device, tested within the Bearing Tester System of the EUCENTRE Foundation Laboratory in Pavia (Italy). The tested isolator was equipped with a special sliding material, made up of a Poly-Tetra-Fluoro-Ethylene-based compound (PTFE), filled with carbon fibers and with a solid lubrication. The hybrid tests were performed, in terms of earthquake simulations, and the response of the base-isolated structural system was computed, by applying single-events, rather than aftershock chains. Results lead to a better understanding of the behavior of sliding-based seismic isolation systems, characterized by medium-to-high tribological properties, in terms of peak and residual displacements for both the single-event and the mean responses. Specifically, this work provides hybrid experimental evidence of the influence of an initial displacement offset on the overall behavior of the considered structural system.