Disease control phase of treatment

Nesbit, Samuel P.; González-Cabezas, Carlos; Reside, Jonathan; Moretti, Antonio; Tawil, Peter Z.; Boushell, Lee W.; Gerdts, George; Lim, Pei Feng

doi:10.1016/b978-0-323-28730-2.00018-2

Cited by 2 publications

(2 citation statements)

References 57 publications

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“…24 Based on the in vitro results obtained in Clinical improvement in the control group may be attributed to the removal of biofilm via SRP, with reduction in periodontal bacterial load and healing of soft tissues. 35 The superiority of clinical outcomes in the test group may be ascribed to the selective bactericidal effect of NTZ against anaerobic bacteria which cause periodontitis 14,15 and to its anti-inflammatory effect. 16,17 The improved clinical outcomes of SRP by locally-delivered NTZ is in accordance with previous studies of topical antibiotics used for the treatment of periodontitis.…”

Section: Discussionmentioning

confidence: 99%

Nitazoxanide as a new local adjunctive to nonsurgical treatment of stage II periodontitis: Clinical and Biochemical evaluation

Taalab

Makled

El-Khordagui

et al. 2022

Egyptian Dental Journal

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Objectives: This study evaluated the effect of Nitazoxanide (NTZ) delivered subgingivally as thermosensitive hydrogel on the clinical and biochemical outcomes of scaling and root planing (SRP) compared to SRP alone in patients with stage II periodontitis. Materials and Methods:A randomized, controlled clinical trial was conducted on forty adult patients equally divided between a control group treated with full-mouth SRP and a test group treated with SRP and sub gingivally-delivered 0.01% NTZ gel. The gel was administered twice, one week after SRP and a week later. Probing depth (PD), clinical attachment level (CAL), bleeding on probing (BOP), gingival index (GI), and matrix metalloproteinase-8 (MMP-8) levels in gingival crevicular fluid (GCF) were measured at baseline and after 3 and 6 months and compared in addition to the reduction in these values from baseline to 6 months using Mann-Whitney U test.Results: There were significantly greater reductions in the test than the control groups at 6 months regarding PD (mean= 3.1mm and 2.3mm, P= 0.001), CAL (2.3mm and 1.7mm, P= 0.013), percentage of sites with BOP (mean= 1.6% and 1%, P= 0.001), GI (mean= 2.3 and 1.6, P= 0.006), and MMP-8 level (mean= 1.8 and 0.9, P= 0.028).Conclusions: NTZ has potential when combined with SRP as an adjunctive for the treatment of stage II periodontitis, offering added benefit over SRP alone based on clinical and biochemical findings. Trial registration:The study was retrospectively registered at clinicaltrials.gov, NCT04768530 on 24/2/2021.

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Section: Discussionmentioning

confidence: 99%

Nitazoxanide as a new local adjunctive to nonsurgical treatment of stage II periodontitis: Clinical and Biochemical evaluation

Taalab

Makled

El-Khordagui

et al. 2022

Egyptian Dental Journal

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“…Accordingly, myalgia has been referred to as muscular rheumatism [ 5 ]. Myalgia is diagnosed by clinical examination, and hypersensitive spots (trigger points) are typical findings [ 6 , 7 ]. These spots are located by palpating within a taut band of muscle fibers [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Intrafasciomembranal Fluid Pressure: A Novel Approach to the Etiology of Myalgias

Hopen¹

2022

Cureus

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Fascia is a continuous membrane (fasciomembrane) that enables differentiation of fluid pressure on either side. Fascia membrane also enables an internal increased fluid pressure at all muscle levels (fibers, fiber bundles, skeletal muscles, compartments), and the author introduces a new unifying term for these pressures, regardless of the anatomical level - the intrafasciomembranal fluid pressure (IFMFP). Swelling, pain, and loss of tissue function are identified as common cardinal symptoms in trigger point (TrP), chronic exertional compartment syndrome (CECS), overtraining syndrome (OTS), and delayed onset muscle soreness (DOMS). Existing literature and an overall assessment indicate that intramuscular conditions related to fluid flow and pressure play a central role in different conditions, providing a common biomechanical explanation of the etiology and influence, supporting the article's theory that an increased IFMFP plays a key role in these conditions.

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Disease control phase of treatment

Cited by 2 publications

References 57 publications

Nitazoxanide as a new local adjunctive to nonsurgical treatment of stage II periodontitis: Clinical and Biochemical evaluation

Nitazoxanide as a new local adjunctive to nonsurgical treatment of stage II periodontitis: Clinical and Biochemical evaluation

Intrafasciomembranal Fluid Pressure: A Novel Approach to the Etiology of Myalgias

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