Disease profile of 400 institutionalized mentally retarded patients in Kuwait

Abstract

Farag TI, Al‐Awadi SA, El‐Badramary MH, Aref MA, Kasrawi B, Krishna Murthy DS, El‐Khalifa MY, Yadav G, Marafie MJ, Bastaki L, Wahba RA, Mohammed FM, Abul Hasan S, Redha AA, Redha MA, Al‐aboud H, Al‐Hijji S, Al‐Dighashem D, Al‐Hashash N, Al‐Jeeryan L, Al‐Khor‐afi H, Qurban EA, Al‐Sulaiman I. Disease profile of 400 institutionalized mentally retarded patients in Kuwait. Clin Genet 1993: 44: 329–334. © Munksgaard, 1993 In this preliminary report we summarize the results of a 4‐year multidisciplinary systematic, etiological clinicogenetic survey of 400 institutionalized mentally retarded patients in Kuwait. All had an intelligence quotient below 50. A constitutional disorder, as the direct cause of the mental retardation, was found in 203 patients (50.75%)): a chromosomal abnormality in 37 (9.25%), Mendelian disorders in 137 (34.25%), MCA/MR in 22 (5.55%) and CNS malformations in 7 cases (1.75%). In 157 patients (39.35%) a pre‐, peri or postnatal cause was ascertained. No etiological diagnosis was detected in 40 patients (10%). A detailed analysis of the “disease profile” is given and compared with the results of previous diagnostic genetic surveys among different institutionalized mentally retarded populations in Western and developing countries.

PhenomAD-NDD: the Phenomics Aggregation Database of comorbidities in 51,227 pediatric individuals with NeuroDevelopmental Disorders

“…Although he mainly focused on inheritance patterns and looking at nature versus nurture effects, he also reported congenital malformations in this cohort. Despite almost a century of additional research, of which many reported on associated clinical features in individuals with NDD [2][3][4][5][6][7][8][9][10][11][12][13][14][15], only the prevalence of comorbid mental health disorders and epilepsy (respectively up to 40% and 26%) have been determined [16,17]. For most specific phenotypic characteristics the overall prevalence, however, eludes us, although these additional phenotypic features are essential when taking care of a child with developmental delay (DD) or intellectual disability (ID).…”