Disentangling common and specific neural subprocesses of response inhibition

Sebastian, Alexandra; Pohl, Michael; Klöppel, Stefan; Feige, Bernd; Lange, Thomas; Stahl, Christoph; Voss, Andreas; Klauer, Karl Christoph; Lieb, Klaus; Tüscher, Oliver

doi:10.1016/j.neuroimage.2012.09.020

Cited by 160 publications

(187 citation statements)

References 66 publications

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“…The Go/No-go task, on the other hand, where a prepotent response tendency has to be inhibited on a minority of trials, would engage the 'action withholding' component. Finally, in the stop-signal task, 'action cancelation' would be needed to inhibit responses that have already been initiated (Sebastian et al, 2013). When coupling these insights to our study, the lack of a strong association between the deception task and the stop-signal task may be explained by their reliance on different inhibitory subcomponents.…”

Section: Lying Proficiency Across Lifementioning

confidence: 67%

“…One explanation may be the cognitively and neurally multifaceted character of response inhibition (Wager et al, 2005). Different response inhibition paradigms may tap into different subcomponents of response inhibition that recruit partially distinct regions of the neural inhibition network (Aron, 2011;Eagle, Bari, & Robbins, 2008;Jahfari et al, 2011;Nigg, 2000;Sebastian et al, 2013;Swick, Ashley, & Turken, 2011). The Stroop task and Simon task, for example, would tap into 'interference inhibition', as they involve the inhibition of unintentionally activated response tendencies.…”

Section: Lying Proficiency Across Lifementioning

confidence: 99%

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From junior to senior Pinocchio: A cross-sectional lifespan investigation of deception

et al. 2015

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We present the first study to map deception across the entire lifespan. Specifically, we investigated age-related difference in lying proficiency and lying frequency. A large community sample (n = 1005) aged between 6 and 77 were surveyed on their lying frequency, and performed a reaction-time (RT) based deception task to assess their lying proficiency. Consistent with the inverted U-shaped pattern of age-related changes in inhibitory control that we observed in a stop signal task, we found that lying proficiency improved during childhood (in accuracy, not RTs), excelled in young adulthood (in accuracy and RTs), and worsened throughout adulthood (in accuracy and RTs). Likewise, lying frequency increased in childhood, peaked in adolescence, and decreased during adulthood. In sum, we observed important age-related difference in deception that generally fit with the U-shaped pattern of age-related changes observed in inhibitory control. Theoretical and practical implications are discussed from a cognitive view of deception.

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Section: Lying Proficiency Across Lifementioning

confidence: 67%

Section: Lying Proficiency Across Lifementioning

confidence: 99%

From junior to senior Pinocchio: A cross-sectional lifespan investigation of deception

et al. 2015

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“…Performance on the go/no-go is not associated with SST performance in children with ADHD [84], and in adults, tDCS treatment targeting the left DLPFC increased the proportion of correct responses in the “go stage” of the go/no-go test compared to sham [85]. It is possible that impulsivity consists of multiple components, and component-specific assessment of impulse control in healthy participants has revealed different activation patterns of the neural impulse control network [86, 87]. Therefore, the absence of tDCS effects on other CPT outcomes, such as true positive errors and reaction time, may be due to differences in inhibitory processes for false positive versus true positive errors.…”

Section: Discussionmentioning

confidence: 99%

Transcranial direct current brain stimulation decreases impulsivity in ADHD

et al. 2018

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Background Impulsivity is a core deficit in attention deficit hyperactivity disorder (ADHD). Transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex (DLPFC) has been shown to modulate cognitive control circuits and could enhance DLPFC activity, leading to improved impulse control in ADHD. Objective/Hypothesis We predicted 2.0 mA anodal stimulation (tDCS) versus sham stimulation applied over the left DLPFC would improve Conners Continuous Performance Task (CPT) scores. Our secondary hypothesis predicted that stop signal task (SST) reaction time would decrease with tDCS (versus sham). Methods Thirty-seven participants completed two periods of three tDCS (or sham) sessions two weeks apart in a within-subject, double-blind, counterbalanced order. Participants performed a fractal N-back training task concurrent with tDCS (or sham) stimulation. Participants completed the CPT and SST at the beginning of treatment (baseline), at the end of the treatment, and at a 3-day post-stimulation follow-up. Results There was a significant stimulation condition by session interaction for CPT false positive scores (χ2 =15.44, p<0.001) driven by a decrease in false positive errors from baseline to end of treatment in the tDCS group (β=−0.36, 95% Confidence Interval (CI) −0.54 to −0.18, p<0.001). This effect did not persist at follow-up (β=−0.13, p>0.05). There was no significant stimulation condition by session interaction effect on CPT true positive errors or response time (ps>0.05). No significant change in SSRT performance was observed (p>0.05). Conclusion These findings suggest that stimulation of the left DLPFC with tDCS can improve impulsivity symptoms in ADHD, supporting the therapeutic potential for tDCS in adult ADHD patients.

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“…Impulsivity consists of different components including personality traits (eg, tendency to act on the spur of the moment), deficits in executive functions (eg, attention, interference inhibition, information sampling, decision making, delay of gratification), and behavioral inhibition (Sebastian et al, 2013(Sebastian et al, , 2014. Aggressive behavior frequently displayed by patients with BPD (Latalova and Prasko, 2010) and ADHD (Connor et al, 2010) is usually of two different kinds: reactive (or impulsive) aggression and instrumental aggression.…”

Section: Introductionmentioning

confidence: 99%

Impulsivity and Aggression in Female BPD and ADHD Patients: Association with ACC Glutamate and GABA Concentrations

Ende

Cackowski

Eijk

et al. 2015

Neuropsychopharmacol

127

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Borderline personality disorder (BPD) and attention-deficit-hyperactivity disorder (ADHD) are both characterized by high impulsivity and difficulties in controlling anger and aggression. In BPD, comorbid ADHD may further increase impulsivity. For both disorders, altered MR spectroscopy levels of the neurotransmitters glutamate and GABA as well as some correlations with impulsivity were previously reported. The objective of this study was to investigate the neurotransmitters glutamate and GABA in relation to impulsivity and aggression as expressed in the anterior cingulate cortex (ACC) in groups of female patients with BPD and ADHD, respectively. Associations of glutamate and GABA levels with further BPD (symptom severity) and ADHD aspects (hyperactivity and inattention) were exploratively evaluated. 1H MR spectra were acquired at 3T to determine glutamate to total creatine ratios (Glu/tCr) and GABA levels from the ACC in a BPD group (n = 26), an ADHD group (n = 22), and a healthy control (HC) group (n = 30); all participants were females. Both patient groups showed higher scores on self-reported impulsivity, anger, and aggression compared with HCs. ACC GABA levels were significantly lower in ADHD than HC. Although measures of impulsivity were positively related to glutamate and negatively to GABA, for aggression only a negative correlation with GABA could be demonstrated. These data provide human in vivo evidence for the role of ACC Glu/tCr and GABA in impulsivity and aggression. If distinct associations of Glu/tCr and GABA for BPD and ADHD can be confirmed in future studies, this might yield implications for more specific pharmacological treatments.

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Disentangling common and specific neural subprocesses of response inhibition

Cited by 160 publications

References 66 publications

From junior to senior Pinocchio: A cross-sectional lifespan investigation of deception

From junior to senior Pinocchio: A cross-sectional lifespan investigation of deception

Transcranial direct current brain stimulation decreases impulsivity in ADHD

Impulsivity and Aggression in Female BPD and ADHD Patients: Association with ACC Glutamate and GABA Concentrations

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