Disentangling Genetic, Environmental, and Rater Effects on Internalizing and Externalizing Problem Behavior in 10-year-old Twins

Bartels, Meike; Boomsma, Dorret I.; Hudziak, James J.; Rietveld, M.J.H.; Beijsterveldt, Toos C. E. M. van; Oord, Edwin J. C. G. van den

doi:10.1375/twin.7.2.162

Cited by 27 publications

(39 citation statements)

References 58 publications

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“…Two factors could have given rise to this. First, as noted by those authors, shared environmental effects could represent a bias on the part of the rater, as has been shown for other behavioral problems rated by parents (Bartels et al 2004;Neale and Stevenson 1989); why this effect might be larger in the Dutch study that in our study is not known. Second, there could have been heterogeneity between the two samples for such shared environmental influences as neighborhood SES or co-parent violence (Beyers et al 2001;Farver et al 2005;Tremblay et al 2004), risk factors related to aggressive behavior during the ages examined here.…”

Section: Developmental Genetic Analysesmentioning

confidence: 56%

Genes and Developmental Stabiltiy of Aggressive Behavior Problems at Home and School in a Community Sample of Twins Aged 7–12

et al. 2006

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Though behavioral genetic studies of aggression have implicated heritable and environmental factors, there is limited understanding of how these factors influence aggression across different settings and over time. Ratings for 732 twins were collected from parents and teachers during middle childhood and early adolescence. Total aggression scores on the Child Behavioral Checklist (CBCL) and Teacher Report Form (TRF) were examined at each age, across both settings, and developmentally. In this sample, aggressive behavior was moderately to largely heritable at each age within the home (.76-.84) and school (.42-.61). Across each age, ratings by parents and teachers were moderately correlated (.19-.36). Genetic and environmental effects that were limited to a particular setting were important etiological factors for aggressive behavior consistently within each setting, while only genetic factors influenced levels of aggression across both settings. Stability during these ages was due to genetic effects common to each age and the persistence of child-specific environmental experiences within each setting. These results suggest that genetic and environmental influences on children's aggressive behavior are largely setting specific. Levels of aggression seen consistently across both settings are due to genetic influences. Developmentally stable levels of aggressive behavior result from genetic influences common to all ages and individual environmental influences whose effects persist across ages.

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Section: Developmental Genetic Analysesmentioning

confidence: 56%

Genes and Developmental Stabiltiy of Aggressive Behavior Problems at Home and School in a Community Sample of Twins Aged 7–12

et al. 2006

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“…Second, we observed that shared environmental influences were moderate for the parent‐report‐based p factor, but negligible for self‐ and teacher‐rated p, respectively. This pattern of results is most likely due to rater bias in that parent ratings are based on a single informant rating both twins, whereas for teacher and self‐ratings different informants rate each twin (Bartels et al., ).…”

Section: Discussionmentioning

confidence: 99%

The p factor: genetic analyses support a general dimension of psychopathology in childhood and adolescence

Allegrini

Cheesman

Rimfeld

et al. 2019

Child Psychology Psychiatry

160

146

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Background Diverse behaviour problems in childhood correlate phenotypically, suggesting a general dimension of psychopathology that has been called the p factor. The shared genetic architecture between childhood psychopathology traits also supports a genetic p. This study systematically investigates the manifestation of this common dimension across self‐, parent‐ and teacher‐rated measures in childhood and adolescence. Methods The sample included 7,026 twin pairs from the Twins Early Development Study (TEDS). First, we employed multivariate twin models to estimate common genetic and environmental influences on p based on diverse measures of behaviour problems rated by children, parents and teachers at ages 7, 9, 12 and 16 (depressive traits, emotional problems, peer problems, autism traits, hyperactivity, antisocial behaviour, conduct problems and psychopathic tendencies). Second, to assess the stability of genetic and environmental influences on p across time, we conducted longitudinal twin modelling of the first phenotypic principal components of childhood psychopathological measures across each of the four ages. Third, we created a genetic p factor in 7,026 unrelated genotyped individuals based on eight polygenic scores for psychiatric disorders to estimate how a general polygenic predisposition to mostly adult psychiatric disorders relates to childhood p. Results Behaviour problems were consistently correlated phenotypically and genetically across ages and raters. The p factor is substantially heritable (50%–60%) and manifests consistently across diverse ages and raters. However, residual variation in the common factor models indicates unique contributions as well. Genetic correlations of p components across childhood and adolescence suggest stability over time (49%–78%). A polygenic general psychopathology factor derived from studies of psychiatric disorders consistently predicted a general phenotypic p factor across development (0.3%–0.9%). Conclusions Diverse forms of psychopathology generally load on a common p factor, which is highly heritable. There are substantial genetic influences on the stability of p across childhood. Our analyses indicate genetic overlap between general risk for psychiatric disorders in adulthood and p in childhood, even as young as age 7. The p factor has far‐reaching implications for genomic research and, eventually, for diagnosis and treatment of behaviour problems.

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“…The higher estimates of shared environmental effects in parent-reported data might be due to shared rater effects (Bartels et al 2004). We found similar moderate estimate of genetic influences on parent-report compared to self-report, which was consistent with previous studies with multiple informants (Happonen et al 2002).…”

Section: Discussionmentioning

confidence: 99%

Genetic and Environmental Influences on Depressive Symptoms in Chinese Adolescents

Chen

Natsuaki

et al. 2013

Behav Genet

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Adolescent depression is common and has become a major public health concern in China, yet little research has examined the etiology of depression in Chinese adolescents. In the present study, genetic and environmental influences on Chinese adolescent depressive symptoms were investigated in 1181 twin pairs residing in Beijing, China (ages 11 to 19 years). Child- and parent-versions of the Children’s Depression Inventory (CDI) were used to measure adolescents’ depressive symptoms. For self-reports, genetic factors, shared environmental factors, and non-shared environmental factors accounted for 50%, 5%, and 45% of the variation in depressive symptoms, respectively; for parent-reports, genetic factors, shared environmental factors, and non-shared environmental factors accounted for 51%, 18%, and 31% of the variation, respectively. These estimates are generally consistent with previous findings in Western adolescents, supporting the cross-cultural generalizability of etiological model of adolescent depression. Neither qualitative nor quantitative sex differences were found in the etiological model. Future studies are needed to investigate how genes and environments work together (gene-environment interaction, gene-environment correlation) to influence depression in Chinese adolescents.

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Disentangling Genetic, Environmental, and Rater Effects on Internalizing and Externalizing Problem Behavior in 10-year-old Twins

Cited by 27 publications

References 58 publications

Genes and Developmental Stabiltiy of Aggressive Behavior Problems at Home and School in a Community Sample of Twins Aged 7–12

Genes and Developmental Stabiltiy of Aggressive Behavior Problems at Home and School in a Community Sample of Twins Aged 7–12

The p factor: genetic analyses support a general dimension of psychopathology in childhood and adolescence

Genetic and Environmental Influences on Depressive Symptoms in Chinese Adolescents

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