Disinfection of dentinal tubules with diclofenac sodium and N‐Acetylcysteine compared with calcium hydroxide as intracanal medicaments against Enterococcus faecalis

Abstract

The purpose of this study was to evaluate the disinfection of dentinal tubules with diclofenac sodium (DS), N‐acetylcysteine (NAC) and calcium hydroxide (CH). Contaminated dentinal blocks were divided into two control and seven experimental groups (n = 15): CH, DS, NAC, CH + 5% DS, 50% CH + 50% DS, CH + 5% NAC and 50% CH + 50% NAC. After seven days, dentine debris was obtained from two depths of 100 and 200 µm. The bacterial load was assessed by counting the number of colony‐forming units (CFUs). Pure DS exhibited maximum antibacterial activity at both depths. At 200 µm, it showed statistically significant differences with all the other groups (P < 0.05). Mixing CH with either 5% or 50% of DS and NAC did not increase the antibacterial efficacy (P > 0.05). Pure DS was most effective in disinfecting dentinal tubules, and mixing CH with DS or NAC is not recommended.

Antibacterial and anti-inflammatory efficacy of N-acetyl cysteine in endodontic treatment: a scoping review

“…Three of these studies were conducted in India [ 34 , 38 , 39 ], two in Korea [ 14 , 37 ], two in Turkey [ 33 , 35 ], two in Brazil [ 32 , 40 ], two in Iran [ 41 , 43 ], and one each in Egypt [ 31 ], Singapore [ 30 ], Indonesia [ 36 ] and Spain [ 42 ]. Ten studies [ 14 , 30 , 31 , 34 , 35 , 37 – 41 , 43 ] included sound extracted single-rooted teeth (central incisors or premolars) while three studies [ 14 , 36 , 42 ] took the bacterial sample directly from patients with non-vital teeth. The sample size differed greatly among the included studies, ranging from 16 to 120 teeth [ 14 , 30 , 31 , 34 , 35 , 37 – 39 , 41 ].…”

“…Ten studies [ 14 , 30 , 31 , 34 , 35 , 37 – 41 , 43 ] included sound extracted single-rooted teeth (central incisors or premolars) while three studies [ 14 , 36 , 42 ] took the bacterial sample directly from patients with non-vital teeth. The sample size differed greatly among the included studies, ranging from 16 to 120 teeth [ 14 , 30 , 31 , 34 , 35 , 37 – 39 , 41 ].…”

“…While NAC was equivalent to CHX and calcium hydroxide in two studies. Contrastingly, two studies [ 35 , 41 ] reported inferior efficacy for NAC compared to taurolidine and calcium hydroxide. It seems that there are minor discrepancies among the results of the included studies which can be attributed to the different methodologies such as concentration of the tested agents, targeted microorganism, and assessment methods.…”

“…Table 1 presents comprehensive details on the characteristics of the included studies. In brief, a total of 15 studies (555 teeth) were included in the present review [14,[30][31][32][33][34][35][36][37][38][39][40][41][42][43]. Of these 12 were in-vitro studies [14,30,31,[33][34][35][36][37][38][39][40][41] and one was a randomized clinical trial [32].…”

“…In brief, a total of 15 studies (555 teeth) were included in the present review [14,[30][31][32][33][34][35][36][37][38][39][40][41][42][43]. Of these 12 were in-vitro studies [14,30,31,[33][34][35][36][37][38][39][40][41] and one was a randomized clinical trial [32]. Three of these studies were conducted in India [34,38,39], two in Korea [14,37], two in Turkey [33,35], two in Brazil [32,40], two in Iran [41,43], and one each in Egypt [31], Singapore [30], Indonesia [36] and Spain [42].…”