Disinfection, sterilization, and antisepsis: An overview

Rutala, William A.; Weber, David J.

doi:10.1016/j.ajic.2015.10.038

Cited by 137 publications

(107 citation statements)

References 44 publications

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“…By definition, SCCED are noninfected ulcers. However, the combination of a chronically ulcerated cornea, surface microbiota, and the utilization of a reusable surgical instrument can potentiate complications including infection, fibrosis, and prolonged healing times; pre‐sterilization cleaning procedures decrease the risk of infection substantially and have been established for reusable surgical instruments …”

Section: Discussionmentioning

confidence: 99%

Comparison of two cleaning and sterilization protocols of diamond burr tips used in debridement for canine superficial chronic corneal epithelial defects

Banks

Stalla

Bunyak

et al. 2019

Veterinary Ophthalmology

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Objectives To serially evaluate morphologic and elemental composition changes to diamond burr tips (DBTs) comparing two sterilization protocols. Animals studied A total of 300 fresh cadaver porcine globes. Procedures Six DBTs were randomly, equally assigned into Group 1 or 2, and then analyzed using Scanning Electron Microscopy (SEM) and Energy Dispersive Spectroscopy (EDS) at 0, 25, 50, and 100 cycles. Diamond burr debridement (DBD) was performed for 120 seconds on corneal stroma using the Algerbrush®. DBTs were cleaned, and then: Group 1 was sterilized by Germinator 500™; and Group 2 underwent ultrasonic cleaning and pre‐vacuum autoclave. A cycle is defined as one DBD, cleaning and sterilization protocol. Data were quantified using custom MatLab program. Results Energy Dispersive Spectroscopy revealed minor buildup of sulfur on both groups. Group 1 displayed major buildup of carbon and calcium. All DBTs were stippled with inorganic particulate at baseline. Particulates were no longer present on Group 2 by 25 cycles, but remained on Group 1 at all time points. There was significantly more buildup on Group 1 at all time points (P = 0.0000, 0.0009, and 0.0003 for 25, 50, and 100 cycles, respectively). More damage to Group 2 at all time points (P = 0.003, 0.002, and 0.003 for 25, 50, and 100 cycles, respectively) was observed. Conclusions No significant damage to Group 1 DBTs was noted after 100 cycles, however, particulate matter is not adequately removed using this sterilization technique. Ultrasonic cleaning is warranted between DBDs to achieve adequate particulate removal prior to sterilization; greater damage occurs with this technique which supports replacing DBTs regularly.

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Section: Discussionmentioning

confidence: 99%

Comparison of two cleaning and sterilization protocols of diamond burr tips used in debridement for canine superficial chronic corneal epithelial defects

Banks

Stalla

Bunyak

et al. 2019

Veterinary Ophthalmology

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“…Disinfectants are widely used in houses, hospitals, public places, ports and factories. They play an important role in controlling microbial infections (Rutala and Weber ). However, due to the widespread use of disinfectants, microbial resistance is increasing, which minimizes the effectiveness of current bactericidal agents (Rutala and Weber ; Weber et al .…”

Section: Introductionmentioning

confidence: 99%

Bactericidal mechanism of glutaraldehyde-didecyldimethylammonium bromide as a disinfectant againstEscherichia coli

et al. 2017

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Using a low concentration of GA and DDAB, a new combination disinfectant was developed. GA-DDAB displayed higher antimicrobial activity than treatment with GA or DDAB alone. Therefore, GA-DDAB may be a more cost-effective and efficient antimicrobial agent than others in use today. Furthermore, this study provided a paradigm for developing high-efficiency disinfectant to help address the growing problem of bacterial resistance.

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“…The choice of sterilisation method depends on the substances from which the medical product is produced [17,18,19,20].…”

Section: Composite Materials In Medicinementioning

confidence: 99%

Ceramic-polylactide composite material used in a model of healing of osseous defects in rabbits

Myciński¹,

Zarzecka²,

Skórska-Stania³

et al. 2017

pjp

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Disinfection, sterilization, and antisepsis: An overview

Cited by 137 publications

References 44 publications

Comparison of two cleaning and sterilization protocols of diamond burr tips used in debridement for canine superficial chronic corneal epithelial defects

Comparison of two cleaning and sterilization protocols of diamond burr tips used in debridement for canine superficial chronic corneal epithelial defects

Bactericidal mechanism of glutaraldehyde-didecyldimethylammonium bromide as a disinfectant againstEscherichia coli

Ceramic-polylactide composite material used in a model of healing of osseous defects in rabbits

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