Disk diffusion susceptibility testing for LY163892 (KT-3777), a new orally administered 1-carbacephem

Jones, Ronald N.; Barry, Arthur L.

doi:10.1128/jcm.26.4.770-773.1988

J Clin Microbiol

1988

DOI: 10.1128/jcm.26.4.770-773.1988

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Disk diffusion susceptibility testing for LY163892 (KT-3777), a new orally administered 1-carbacephem

Ronald N. Jones¹,

Arthur L. Barry²

Abstract: LY163892, a new orally administered 1-carbacephem, was found to have a spectrum of antimicrobial activity very similar to that of cefaclor. Diffusion tests with 30-,ug LY163892 disks produced acceptable interpretive error rates with-22 mm as the susceptibility zone diameter. This was required to reduce potential false-susceptibility results, particularly among Enterobacter spp. and Providencia stuartii: both species included strains that produce B-lactamases capable of hydrolyzing LY163892. Preliminary recomme… Show more

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Cited by 5 publications

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Interpretive criteria for disk diffusion tests using 5-microgram cefdinir disks with rapidly growing clinical isolates

1992

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Preliminary interpretive zone diameter criteria were calculated for the 5-jig cefdinir disk diffusion test by using two potential MIC breakpoints (.0.5 and s1 ,ug/mi). The absolute agreement between tests ranged from 85.9 to 92.4%, and the false-susceptibility errors were principally contributed by the Enterobacter spp. (2.2% error). One proposed criterion was 220-mm zone diameter (<1 jig/ml) for susceptibility and .16-mm zone diameter (>2 jig/ml) for resistance to cefdinir. Clinical laboratory users of the disk diffusion method should be cautioned about the possibility of very major interpretive errors among enterobacter isolates.

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Interpretive criteria for disk diffusion tests using 5-microgram cefdinir disks with rapidly growing clinical isolates

1992

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Interpretive accuracy of the disk diffusion method for testing newer orally administered cephalosporins against Morganella morganii

1993

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Eight newer orally administered cephems (cefdinir, cefetamet, cefixime, cefpodoxime, cefprozil, ceftibuten, cefuroxime, and loracarbef) were tested against 100 clinical strains of MorganeUla morganii to determine the extent of serious interpretive very major (false-susceptible) errors when current criteria for the disk diffusion test are applied. Agar dilution MICs and disk diffusion tests were performed as recommended by the National Committee for Clinical Laboratory Standards (Villanova, Pa.) (NCCLS), and the methods were compared by regression analysis using the method of least squares and by error rate bounding. The following results are listed in the order of increasing error rates: cefdinir, loracarbef, and cefprozil, <1% very major error; ceftibuten, 8% minor errors; cefuroxime, 21% minor errors; cefixime, cefpodoxime, and cefetamet, very major errors of 15, 24, and 36%, respectively. M. morganii produces unacceptable rates of test error with cefuroxime, cefixime, cefpodoxime, and cefetamet. The latter two cephalosporins currently have NCCLS table footnote warnings covering the problem observed with this organism. The inclusion of cefuroxime and cefixime in the NCCLS table footnote is strongly recommended.

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Predictive accuracy of disk diffusion test for Proteus vulgaris and Providencia species against five newer orally administered cephalosporins, cefdinir, cefetamet, cefprozil, cefuroxime, and loracarbef

Biedenbach

Jones

1994

J Clin Microbiol

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Three members of the tribe Proteeae (Proteus vulgaris, Providencia rettgeri, and Providencia stuartii) were tested against five newer orally administered cephalosporins (cefdinir, cefprozil, cefuroxime, cefetamet, and loracarbef) by the disk diffusion and reference broth microdilution methods. One hundred strains of these organisms were tested to confirm the excessive interpretive error rates that previously had been noted for the disk diffusion test. The results indicate that the suggested disk diffusion breakpoints for cefetamet and cefuroxime were without serious interpretive errors. In contrast, loracarbef, cefdinir, and cefprozil results exceeded acceptable interpretive error rates, with very major (false-susceptible) errors of 4, 5, and 9%o

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Disk diffusion susceptibility testing for LY163892 (KT-3777), a new orally administered 1-carbacephem

Cited by 5 publications

References 11 publications

Interpretive criteria for disk diffusion tests using 5-microgram cefdinir disks with rapidly growing clinical isolates

Interpretive criteria for disk diffusion tests using 5-microgram cefdinir disks with rapidly growing clinical isolates

Interpretive accuracy of the disk diffusion method for testing newer orally administered cephalosporins against Morganella morganii

Predictive accuracy of disk diffusion test for Proteus vulgaris and Providencia species against five newer orally administered cephalosporins, cefdinir, cefetamet, cefprozil, cefuroxime, and loracarbef

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