Dislipidemia and oxidative stress in mild and in severe psoriasis as a risk for cardiovascular disease

Abstract

Psoriasis is a common chronic and recurrent inflammatory skin disorder that has been associated with oxidative stress, abnormal plasma lipid metabolism and with high frequency of cardiovascular events. This prevalence seems to be related to the severity of psoriasis, as it occurs more frequently in patients presenting large areas of the body affected with psoriasis lesions. The aim of our work was to evaluate the development of oxidative stress and of dislipidemia in psoriasis, and to look for a correlation between their levels and worsening of psoriasis. We evaluated lipid profile, total antioxidant capacity, antioxidant vitamins A and E, and lipoperoxidation products. The study was performed in controls and in patients presenting mild and severe psoriasis. Patients presented risk changes in lipid profile (a rise in cholesterol (P<0.01), triglycerides (P<0.001), low density lipoprotein cholesterol (P<0.01), very low density lipoprotein cholesterol (P<0.01), apolipoprotein B (P<0.001) and lipoprotein(a) (P<0.001); and a reduction in high density lipoprotein cholesterol (P<0.001)), a rise in lipoperoxidation products (P<0.001) and a reduction in total antioxidant capacity (P<0.001) and in antioxidant vitamins A (P<0.001) and E (P<0.05). Moreover, we found that the worsening of psoriasis was associated with the enhancement of oxidative stress and of the lipid risk changes. Our data suggest that psoriasis patients must be considered as a group at risk for cardiovascular disease and that this risk seems to be higher in severe psoriasis. In addition, a possible benefit of an enriched diet or of a supplement of vitamins A and E in psoriasis patients should be further studied.

Increased carotid artery intima-media thickness and impaired endothelial function in psoriasis

“…This concurs with two recent studies. 23,25 The mean differences in the IMT and FMD between the groups were also significant in the analysis of covariance adjusted for the HDL. We failed to detect any correlation between the lipid levels and subclinical atherosclerosis indicators.…”

Psoriasis ve metabolik sendrom

“…Son yıllarda psoriasis kardiyak hastalık açısından bağımsız risk faktörü olarak kabul görmekte ve metabolik sendrom ile de yakından ilişkili olduğu bilinmektedir [15][16][17][18] . Psoriatik olgularda metabolik sendrom insidansı ve KVH riski PAŞİ ile ilişkilendirilmiş, tutulan vücut yüzey alanı daha fazla, hastalık süresi daha uzun olanlarda riskin arttığı belirlenmiştir 19 . Çalışmamızda psoriatik olguların %62'sinde metabolik sendrom saptanırken bu oran non-psoriatik olgularda %24'dü ve aralarındaki fark istatistiksel olarak anlamlı bulundu.…”

Lipid profile and its relationship to Oxidant and Antioxidant status in Psoriatic Arthritis

“…A complex network of cytokines and chemokines mediates the pathological reaction in chronic nature of psoriasis. 6 Though conflicting reports are available regarding the serum lipid values in psoriasis 3,7,8,10 , the potential role of lipid abnormality in psoriatic arthritis patients has been discussed. High levels of total cholesterol, triglycerides, VLDL, and LDL-cholesterol in patients of psoriatic arthritis were seen as shown in our table-I.…”

“…1 Psoriatic arthritis is a common chronic and recurrent inflammatory skin and joint disorder 2 that has been associated with abnormal plasma lipid metabolism and high frequency of cardiovascular events. 3 This prevalence seems to be related to the severity of psoriatic arthritis, as it occurs more frequently in patients presenting large areas of the body affected with psoriasis lesions. Though dyslipidemia is known to occur, less is known about its status and association with oxidative stress in patients of psoriatic arthritis.…”