Psoriasis ve metabolik sendrom

Günaydın, Aslı; Aytimur, Derya; Özdemir, Fezal

doi:10.4274/turkderm.57767

Cited by 7 publications

(7 citation statements)

References 13 publications

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“…23 According to the data from the Turkish Metabolic Syndrome Research, conducted in 2004 through screening of 4264 individuals, MBS prevalence was 41.1% in females, 28.8% in males, with an overall of 35%. 24 Günaydın et al 2 had found MBS in 31 (62%) of 50 psoriasis patients when they evaluated MBS components with laboratory investigations including fasting blood glucose, among others. Lower ratios found in our study may have resulted from the assessment of MBS components like diabetes, dyslipidemia and hypertension only in diagnosed patients.…”

Section: Discussionmentioning

confidence: 99%

“… 27 The findings which suggest that cutaneous inflammation and neighboring fat tissue cytokines could induce hyper-proliferation of each other are as follows; i. 2 - 4 Definition of the receptors which mediate early immune response to antigens on the cell surface of adipocytes and release cytokines like interleukin-6 and tumor necrosis factor (TNF)-alpha, which are closely related to psoriasis development, ii. Higher production of circulating TNF-α, soluble TNF-α, and in vitro TNF-α in the obese compared to the non-obese, iii.…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of smoking, alcohol consumption and metabolic syndrome in patients with psoriasis

Adışen

Uzun

Erduran

et al. 2018

An. Bras. Dermatol.

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BackgroundCoexistence of obesity, hypertension, insulin resistance and dyslipidemia is defined as metabolic syndrome (MBS), which is among the important risk indicators for cardiovascular diseases, diabetes and stroke. Smoking and alcohol consumption are the other factors which lead to an increase in the risk of cardiovascular disease.ObjectiveTo investigate the prevalence of metabolic syndrome, smoking and alcohol consumption in psoriasis patients and the relationship between disease severity and these factors.MethodsThis cross-sectional study enrolled 563 patients with chronic plaque-type psoriasis, all of which completed a questionnaire and underwent a complete physical examination. Data about MBS components, psoriasis severity/duration, smoking and alcohol consumption, and cardiovascular diseases were recorded.ResultsA total of 563 patients with ages ranging from 18 to 78 years were evaluated. Metabolic syndrome was found in 12.6% of the patients [central obesity (38.7%), hypertension (14.3%), dyslipidemia (18.6%), diabetes (9.2%)], while 50.3% had smoking, and 3.3% had alcohol consumption. Patients with metabolic syndrome were older and more likely to have a longer disease duration than those without metabolic syndrome (p<0.05 for each). The prevalence of metabolic syndrome was higher in women than in men. Psoriasis was more severe in patients with central obesity, diabetes and smoking than in those without (p<0.05 for each).Study LimitationsRetrospective design.ConclusionsOur results indicate that MBS is a risk factor for psoriasis patients with advanced age. The relationship between disease severity and obesity, diabetes, and smoking in psoriasis patients indicates that the patients should be informed about the potential metabolic risks and receive therapies for behavioral changes besides anti-psoriatic treatment in order to minimize these risks.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prevalence of smoking, alcohol consumption and metabolic syndrome in patients with psoriasis

Adışen

Uzun

Erduran

et al. 2018

An. Bras. Dermatol.

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“…Günaydın var ark. (29) psoriasisli hastaların %62'sinde metabolik sendrom belirlemişlerdir. Tsai ve ark.…”

Section: Discussionunclassified

Retrospective Analysis of Clinical and Sociodemographic Features of Patients with Psoriasis

Topal¹,

Değirmentepe²,

Cüre³

et al. 2017

Okmeydani Medical Journal

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“…Psoriasis vulgaris is a chronic inflammatory disease that is observed in 1%-3% of the general population and is characterized by attack and remission periods (1,2). A combination of insulin resistance and metabolic syndrome (MetS) is commonly observed in psoriasis patients (3)(4)(5)(6). These patients also often suffer from hypertension (HT), heart failure, and diabetes mellitus (DM) (7).…”

Section: Introductionmentioning

confidence: 99%

Serum adropin levels in psoriasis vulgaris and its relation with metabolic parameters

Korkmaz¹,

Özgün²

2019

Turk J Med Sci

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Background/aim: Adropin is a peptide-structure hormone that plays a role in preventing the development of insulin resistance, which has been linked to obesity and metabolic regulation. The purpose of this study is to assess serum adropin levels and their relationship with metabolic parameters in psoriasis vulgaris patients both with and without metabolic syndrome (MetS). Methods: Fifty-three patients and twenty-six healthy controls were included in this study. Serum adropin levels, fasting blood glucose, fasting plasma insulin, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, total cholesterol, and triglyceride levels of all participants were analyzed. Enzyme-linked immunosorbent assay was used to measure serum adropin levels. Results: Serum adropin levels in psoriatic patients without MetS were 2.94±0.56 ng/ml, in psoriasis patients with MetS were 2.49±0.77 ng/ml and were 3.37±0.71 ng/ml in control group. Multivariate logistic regression analysis was used to evaluate adropin decreases in psoriasis patients as an independent predictor in terms of the presence of MetS. Conclusion: The serum levels of adropin in psoriasis patients were significantly lower in the presence of MetS, and this decrease was more prominent than in those without MetS. Adropin may be a responsible factor for metabolic disorders and the development of MetS in psoriasis patients. Key words: Psoriasis, metabolic syndrome, adropin

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Psoriasis ve metabolik sendrom

Cited by 7 publications

References 13 publications

Prevalence of smoking, alcohol consumption and metabolic syndrome in patients with psoriasis

Prevalence of smoking, alcohol consumption and metabolic syndrome in patients with psoriasis

Retrospective Analysis of Clinical and Sociodemographic Features of Patients with Psoriasis

Serum adropin levels in psoriasis vulgaris and its relation with metabolic parameters

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