Dislipidemia y riesgo aterogénico en pacientes con lupus eritematoso sistémico

Garrido, Jessica Roa; Alba, Hugo Alberto Radillo; Núñez, Éufrates Hernández; Olán, Francisco

doi:10.1016/j.medcli.2016.03.030

Cited by 6 publications

(5 citation statements)

References 9 publications

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“…However, in our study, SLE patients presented normal serum levels of lipid pro le, with lower levels of TG, TC, and LDL-C compared with other studies performed in SLE patients [6,33,34]. Serum HDL-C levels in the present study were found within the normal range with higher values compared to other studies [6,33].…”

Section: Discussioncontrasting

confidence: 71%

“…In several studies, SLE patients with dyslipidemia had a higher frequency of glucocorticoid administration, around of 70% [6,35], while in the present study, it was only 31%. In contrast, the antimalarial pharmacotherapy was higher in our study, reaching almost 90% of SLE patients, considering CQ and HCQ administration, while in other studies the combined frequency has been described less than 64% [34,35].…”

Section: Discussioncontrasting

confidence: 66%

“…The differences in the dyslipidemia frequency in our study in comparison to other studies could be explained in part by the low clinical activity disease and the high antimalarial pharmacological treatment observed. A high frequency of SLE patients evaluated in the present study, were in clinical activity remission (63%), in comparison to other studies in SLE patients from other countries, where the general prevalence of SLE patients with clinical activity has been described higher [6,33,35].…”

Section: Discussioncontrasting

confidence: 63%

“…In SLE patients a high frequency of atherogenic dyslipidemia related to cardiovascular risk disease have been described [6,32,33]. A longer disease evolution time, higher corticosteroids cumulative dose, and absence of antimalarial therapy have been described as predictor factors of cardiovascular disease in SLE [32].…”

Section: Discussionmentioning

confidence: 99%

“…Dyslipidemia in SLE is characterized by low serum levels of high-density lipoprotein cholesterol (HDL-C), and high levels of triglycerides (TG), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) [6], and a positive energy balance and obesity are factors that modulate its clinical manifestations [7]. Additionally, corticosteroid pharmacotherapy used in SLE contributes to dyslipidemia development, and high administration of prednisone can stimulate lipolysis, and high fatty acids serum levels [8].…”

Section: Introductionmentioning

confidence: 99%

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Relationship of the Inflammatory Diet Status and Dietary Intake with Antimalarial Treatment in Systemic Lupus Rrythematosus: A Cross-Sectional Study

Meza-Meza

Shivappa

Montoya‐Buelna

et al. 2020

Preprint

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Background: Systemic lupus erythematosus (SLE) is the prototype autoimmune disease with high inflammatory cytokine levels. In autoimmune conditions, diet could modify the inflammatory status, comorbidities and pharmacotherapy administered in SLE patients. The aim of this study was to assess the relationship of the inflammatory diet status and dietary intake with comorbidities and pharmacotherapy administered in SLE patients. Methods: A cross-sectional study was conducted in sixty-eight Mexican-Mestizo female SLE patients. Dietary intake was estimated from three 24h food records by Nutritionist Pro-Diet software and 27 food parameters were used to evaluate the inflammatory diet status by the normal dietary inflammatory index (DII®). Results: SLE patients presented a global pro-inflammatory diet status (DII: 0.71 ± 1.78). Chloroquine (CQ) administration was related to a pro-inflammatory diet status compared to hydroxychloroquine (HCQ) administration, which was related to an anti-inflammatory diet status (CQ= DII score: 1.385±1.327 vs. HCQ= DII score: 0.004±2.024; p=0.002). CQ administration conferred a pro-inflammatory DII score (β coefficient= 1.20; CI: 1–2.02; R2=0.11; p<0.01) and lower total-cholesterol (β coefficient=-29.2; CI: -4.03 to -54.5; R2=0.07; p<0.05); conversely, HCQ administration conferred an anti-inflammatory DII score (β coefficient= -1.29; CI: -0.46 to -2.12; R2=0.13; p<0.01). SLE patients with CQ administration had lower intake of energy and 12 nutrients evaluated (CQ vs. HCQ; p <0.05), and SLE patients with HCQ treatment had a better achievement ≥100% of daily dietary reference intake (DRI) of energy (HCQ 77% vs. CQ 52%; p=0.03), vitamin A (HCQ 65% vs. CQ 29%; p<0.01), cholesterol (HCQ 29% vs. CQ 3%; p<0.01), and fiber (HCQ 26% vs. CQ 6%; p=0.03).Conclusions: In SLE patients the CQ administration was related to a pro-inflammatory diet status and low total-cholesterol, and HCQ administration with an anti-inflammatory diet status and better dietary intake.

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Section: Discussioncontrasting

confidence: 71%

Section: Discussioncontrasting

confidence: 66%

Section: Discussioncontrasting

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Relationship of the Inflammatory Diet Status and Dietary Intake with Antimalarial Treatment in Systemic Lupus Rrythematosus: A Cross-Sectional Study

Meza-Meza

Shivappa

Montoya‐Buelna

et al. 2020

Preprint

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Association of cardiometabolic risk status with clinical activity and damage in systemic lupus erythematosus patients: A cross-sectional study

Campos-López

Meza-Meza

Parra‐Rojas

et al. 2021

Clinical Immunology

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Dysregulated serum lipid profile and its correlation to disease activity in young female adults diagnosed with systemic lupus erythematosus: a cross-sectional study

2020

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Background: Recent studies showed that dyslipidemia could be a critical factor in the progression of cardiovascular disease in systemic lupus erythematosus (SLE). The aim of the present study was to describe the relationship between serum lipid profile and SLE disease activity in young female adults with SLE. Methods: Seventy-one female subjects diagnosed with SLE aged 20~30 years were enrolled. Serum lipid profile including TC, TG, HDL-C, LDL-C, VLDL-C, Apo A, Apo B, and Apo E were evaluated between control and young female SLE patients. Univariate correlation analyses were performed to explore the correlation between serum lipid levels and SLE disease activity. Results: Our results showed that TG and VLDL-C levels were significantly increased in young female SLE as compared to control, with TC, HDL-C, LDL-C, Apo A, and Apo B significantly reduced. Meanwhile, univariate correlation analyses showed negative correlations between SLE disease activity index and HDL-C, LDL-C, Apo A, and Apo B; with positive correlations between SLE disease activity index and TG and VLDL-C. Conclusion: Serum lipid profile was significantly dysregulated in young female SLE patients. Moreover, SLE disease activity was correlated to the serum lipid levels, supporting the notion that the young patients with SLE might also have a higher risk of cardiovascular disease.

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Dislipidemia y riesgo aterogénico en pacientes con lupus eritematoso sistémico

Cited by 6 publications

References 9 publications

Relationship of the Inflammatory Diet Status and Dietary Intake with Antimalarial Treatment in Systemic Lupus Rrythematosus: A Cross-Sectional Study

Relationship of the Inflammatory Diet Status and Dietary Intake with Antimalarial Treatment in Systemic Lupus Rrythematosus: A Cross-Sectional Study

Association of cardiometabolic risk status with clinical activity and damage in systemic lupus erythematosus patients: A cross-sectional study

Dysregulated serum lipid profile and its correlation to disease activity in young female adults diagnosed with systemic lupus erythematosus: a cross-sectional study

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